Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.59 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452221 | 0.87 | CYP2C9 (0.49) | CYP2C9KMT2ACYP2C19MEN1CYP2D6 | |
| SCHEMBL7899623 | 0.85 | CYP2C9 (0.64) | CYP2C9KMT2ACYP2C19MEN1CYP2D6 | |
| SCHEMBL12167909 | 0.84 | CYP2C9 (0.46) | CYP2C9KMT2ACYP2C19MEN1CYP2D6 | |
| SCHEMBL22668298 | 0.83 | MMP9 (0.54) | CYP2C9KMT2ACYP2C19MEN1CYP2D6 | |
| SCHEMBL2587234 | 0.82 | EPHX1 (0.63) | CYP2C19CYP2D6GABBR2GABBR1LMNA | |
| SCHEMBL28419253 | 0.82 | CYP2C9 (0.49) | CYP2C9KMT2ACYP2C19MEN1CYP2D6 | |
| SCHEMBL3911497 | 0.81 | MMP9 (0.52) | CYP2C9KMT2ACYP2C19MEN1CYP2D6 | |
| SCHEMBL10255978 | 0.81 | GABBR2 (0.53) | CYP2C9KMT2ACYP2C19MEN1CYP2D6 | |
| SCHEMBL3916057 | 0.80 | FFAR1 (0.53) | CYP2C19GABBR2GABBR1LMNATSHR | |
| SCHEMBL4956252 | 0.80 | CYP2C9 (0.46) | CYP2C9KMT2ACYP2C19MEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | CYP2C9 4824/4885KMT2A 1523/4885CYP2C19 4710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.