Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | JUN | P05412 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503966 | 1.00 | MAP4K1 (0.39) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL13225923 | 0.89 | MAP4K1 (0.41) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL1571877 | 0.87 | MAP4K1 (0.38) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL1571606 | 0.87 | MAP4K1 (0.38) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL1572755 | 0.87 | MAP4K1 (0.38) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL13225922 | 0.86 | MAP4K1 (0.39) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL1571409 | 0.84 | MAP4K1 (0.42) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL1571762 | 0.82 | MAP4K1 (0.39) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL4423231 | 0.79 | MAP4K1 (0.38) | MAP4K1MAP4K3MAPK8JUNMAPK10 | |
| SCHEMBL1571982 | 0.79 | DDR2 (0.36) | MAP4K1MAP4K3MAPK8JUNMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | AIKAWA MINA | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | MAP4K1 49/4885MAP4K3 43/4885MAPK8 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.