Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.47 |
| ▸ | IL1RN | P18510 | 2/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 3/20 | 0.45 |
| ▸ | METAP2 | P50579 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LAP3 | P28838 | 3/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270986 | 1.00 | ERAP1 (0.47) | ERAP1ERAP2IL1RNCSNK1EANPEP | |
| Hydrochloric Acid SCHEMBL7435119 | 0.98 | ERAP1 (0.46) | ERAP1ERAP2IL1RNCSNK1EANPEP | |
| SCHEMBL8884009 | 0.86 | CSNK1E (0.46) | ERAP1ERAP2IL1RNCSNK1EANPEP | |
| SCHEMBL7362253 | 0.86 | CYP1A2 (0.45) | ERAP1ERAP2IL1RNCSNK1EANPEP | |
| SCHEMBL7362251 | 0.86 | ERAP1 (0.42) | ERAP1ERAP2IL1RNCSNK1EANPEP | |
| SCHEMBL7396180 | 0.82 | CA2 (0.44) | ERAP1ERAP2IL1RNCSNK1EANPEP | |
| SCHEMBL7396177 | 0.82 | CA2 (0.44) | ERAP1ERAP2IL1RNCSNK1EANPEP | |
| SCHEMBL27630320 | 0.82 | CSNK1E (0.53) | ERAP1ERAP2CSNK1EANPEPMETAP2 | |
| SCHEMBL14159706 | 0.82 | ANPEP (0.50) | ERAP1ERAP2ANPEPTSHRSLC6A2 | |
| SCHEMBL2486010 | 0.80 | ANPEP (0.49) | ERAP1ERAP2CSNK1EANPEPMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267609-A1 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | GHOSH ARUN K | 2010-10-21 | — | — | US | disclosed |
| EP-1448218-A4 | BETA-SECRETASE INHIBITORS AND METHODS OF USE | OKLAHOMA MED RES FOUND (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20060234944-A1 | Beta-secretase inhibitors and methods of use | OKLAHOMA MEDICAL RESEACH FOUNDATION (US) | 2006-10-19 | — | — | US | disclosed |
| EP-1448218-A2 | BETA-SECRETASE INHIBITORS AND METHODS OF USE | Oklahoma Medical Research Foundation (US) | 2004-08-25 | — | — | EP | disclosed |
| US-20040121947-A1 | Compounds which inhibit beta-secretase activity and methods of use thereof | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2004-06-24 | — | — | US | disclosed |
| WO-2003039454-A2 | BETA-SECRETASE INHIBITORS AND METHODS OF USE | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2003-05-15 | — | — | WO | disclosed |
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| US-4652551-A | PEPTIDE, HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0172346-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267609-A1 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | BACE2, BACE1, PSEN2 | ERAP1 71/4885ERAP2 103/4885IL1RN 759/4885 |
| US-20060234944-A1 | Beta-secretase inhibitors and methods of use | BACE2, BACE1, PSEN2 | ERAP1 40/4885ERAP2 63/4885IL1RN 568/4885 |
| US-20040121947-A1 | Compounds which inhibit beta-secretase activity and methods of use thereof | BACE2, BACE1, PSEN2 | ERAP1 35/4885ERAP2 66/4885IL1RN 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.