Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PTGFR | P43088 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PTGIR | P43119 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507042 | 1.00 | NFE2L2 (0.40) | NFE2L2PTGER3PTGER2PTGER4ALDH1A1 | |
| SCHEMBL13225685 | 0.79 | NFE2L2 (0.40) | NFE2L2PTGER3PTGER2PTGER4ALDH1A1 | |
| SCHEMBL11549449 | 0.78 | CA12 (0.46) | PTGER3PTGER2PTGER4ALDH1A1KDM4E | |
| SCHEMBL11549443 | 0.78 | CA12 (0.46) | PTGER3PTGER2PTGER4ALDH1A1KDM4E | |
| SCHEMBL18802206 | 0.78 | NFE2L2 (0.50) | NFE2L2PTGER3PTGER2PTGER4ALDH1A1 | |
| SCHEMBL28548965 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL7110907 | 0.77 | LMNA (0.46) | NFE2L2PTGER3PTGER2PTGER4PTGDR | |
| SCHEMBL1823411 | 0.76 | LY96 (0.46) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL6821253 | 0.76 | NFE2L2 (0.47) | NFE2L2PTGER3PTGER2PTGER4ALDH1A1 | |
| SCHEMBL6821249 | 0.76 | NFE2L2 (0.47) | NFE2L2PTGER3PTGER2PTGER4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210635-A1 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-19 | — | — | US | disclosed |
| EP-1999117-A2 | RENIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007117961-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210635-A1 | RENIN INHIBITORS | REN, ACE, AGT | NFE2L2 4622/4885PTGER3 415/4885PTGER2 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.