Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27122616 | 0.91 | MAPT (0.45) | MAPTRAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL21707908 | 0.90 | TSHR (0.48) | TSHRMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL3512088 | 0.86 | AKR1C3 (0.46) | TSHRMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL1750741 | 0.85 | ESR1 (0.52) | TSHRMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3514864 | 0.83 | TSHR (0.49) | TSHRMAPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL22749339 | 0.81 | MAPT (0.52) | MAPTRAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL268658 | 0.80 | TDP1 (0.55) | MAPTRAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL1663359 | 0.80 | MAPT (0.55) | TSHRMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL29091595 | 0.80 | MAPT (0.55) | MAPTRAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL27038541 | 0.79 | MAPT (0.48) | TSHRMAPTRAB9AKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305207-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | GLAXOSMITHKLINE LLC | 2010-12-02 | — | — | US | disclosed |
| EP-2195287-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | GlaxoSmithKline LLC (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009045830-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305207-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | PYGM, PYGL, G6PC1 | TSHR 4714/4885MAPT 387/4885RAB9A 3919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.