Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.44 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3497543 | 0.85 | MAPT (0.41) | ALDH1A1HPGDLGALS3LGALS4MAPT | |
| SCHEMBL31391703 | 0.85 | MAPT (0.55) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3092769 | 0.85 | MAPT (0.55) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL539834 | 0.83 | TDP1 (0.47) | ALDH1A1MEN1KMT2AGAALGALS3 | |
| SCHEMBL3512410 | 0.83 | TSHR (0.48) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL29024711 | 0.81 | KDM4E (0.45) | ALDH1A1KDM4EGAAHSD17B10LGALS3 | |
| SCHEMBL15525613 | 0.80 | TSHR (0.68) | TSHRALDH1A1MEN1KMT2AGLA | |
| SCHEMBL8788538 | 0.78 | CYP3A4 (0.49) | TSHRALDH1A1KMT2AHSD17B10LGALS3 | |
| SCHEMBL28999453 | 0.77 | ALDH1A1 (0.49) | TSHRALDH1A1KMT2AKDM4EGAA | |
| SCHEMBL8991985 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KMT2AGLAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305207-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | GLAXOSMITHKLINE LLC | 2010-12-02 | — | — | US | disclosed |
| EP-2195287-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | GlaxoSmithKline LLC (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009045830-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305207-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | PYGM, PYGL, G6PC1 | TSHR 4714/4885ALDH1A1 3219/4885MEN1 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.