Methestrol

Methestrol

SCHEMBL351267

CCC(c1ccc(O)c(C)c1)C(CC)c1ccc(O)c(C)c1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHBG P04278 1/20 0.58
ESR1 P03372 11/20 0.54
AR P10275 5/20 0.54
ALOX15 P16050 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
LMNA P02545 1/20 0.54
CYP1A2 P05177 1/20 0.54
PGR P06401 1/20 0.54
CHRM2 P08172 1/20 0.54
CYP3A4 P08684 1/20 0.54
ADORA3 P0DMS8 1/20 0.54
CYP2D6 P10635 1/20 0.54
MAPT P10636 1/20 0.54
CHRM1 P11229 1/20 0.54
CYP2C9 P11712 1/20 0.54
DRD1 P21728 1/20 0.54
TBXA2R P21731 1/20 0.54
PTGS1 P23219 1/20 0.54
SLC6A2 P23975 1/20 0.54
CYP2C19 P33261 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methestrol SCHEMBL31290837 1.00 SHBG (0.58) SHBGESR1ARALOX15TDP1
SCHEMBL21983353 0.90 SHBG (0.49) SHBGESR1ARALOX15TDP1
SCHEMBL6260738 0.83 ESR1 (0.48) SHBGESR1ARALOX15TDP1
SCHEMBL31545996 0.83 PTGS1 (0.61) SHBGESR1ARALOX15TDP1
SCHEMBL529617 0.83 ESR1 (0.48) ESR1ARALOX15TDP1PTGS1
SCHEMBL29459520 0.83 ESR1 (0.48) ESR1ARALOX15TDP1PTGS1
SCHEMBL13698041 0.82 CYP3A4 (0.47) ESR1ARTDP1LMNACYP1A2
SCHEMBL97663 0.82 GAA (0.65) ESR1ARALOX15TDP1LMNA
SCHEMBL5709894 0.80 ESR1 (0.46) SHBGESR1ARALOX15TDP1
SCHEMBL217919 0.78 TP53 (0.54) ESR1ARALOX15TDP1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 492 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2023-03-23 US claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2022182523-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2021158573-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2021-08-12 WO claimed
WO-2021158575-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2021-08-12 WO claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20110003748-A1 Method of treatment and compositions of D-chiro inositol and phosphates thereof JENNINGS-SPRING BARBARA L 2011-01-06 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
US-20090214474-A1 Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development JENNINGS BARBARA BROOKE 2009-08-27 US claimed
WO-2005065185-A2 TEMPERATURE-STABLE FORMULATIONS, AND METHODS OF DEVELOPMENT THEREOF COLLEGIUM PHARMACEUTICALS, INC. (US) 2005-07-21 WO claimed
US-20050153946-A1 Temperature-stable formulations, and methods of development thereof COLLEGIUM PHARMACEUTICALS, INC. (US) 2005-07-14 US claimed
EP-1443939-A1 COMPOSITIONS FOR TREATMENT OF POSTMENOPAUSAL FEMALE SEXUAL DYSFUNCTION Pharmacia Corporation (US) 2004-08-11 EP claimed
US-20030130244-A1 Compositions for treatment of postmenopausal female sexual dysfunction PHARMACIA CORPORATION 2003-07-10 US claimed
WO-2003039553-A1 COMPOSITIONS FOR TREATMENT OF POSTMENOPAUSAL FEMALE SEXUAL DYSFUNCTION PHARMACIA CORPORATION (US) 2003-05-15 WO claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0046270-B1 NOVEL DERIVATIVES OF BIO-AFFECTING PHENOLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM INTERx RESEARCH CORPORATION (US) 1986-05-21 EP claimed
EP-0046270-A1 Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them INTERx RESEARCH CORPORATION (US) 1982-02-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES FABP2, FABP4, GUSB SHBG 67/4885ESR1 1524/4885AR 1999/4885
US-20110003748-A1 Method of treatment and compositions of D-chiro inositol and phosphates thereof PPIP5K2, SHBG, CYP24A1 SHBG 2/4885ESR1 468/4885AR 853/4885
US-20090214474-A1 Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development SHH, ERH, CDK5 SHBG 2076/4885ESR1 903/4885AR 808/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.