Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12742401 | 0.82 | PTPRB (0.49) | SIRT1ALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL3513099 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPK1SMN1; SMN2GAA | |
| SCHEMBL2175797 | 0.82 | SMN1; SMN2 (0.50) | SIRT1ALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL3513842 | 0.81 | NPC1 (0.54) | ALDH1A1MAPK1SMN1; SMN2GAAHSD17B10 | |
| SCHEMBL1030124 | 0.79 | PI4KB (0.50) | SIRT1ALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL16123390 | 0.78 | SIRT1 (0.52) | SIRT1ALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL6679893 | 0.78 | SIRT1 (0.49) | SIRT1ALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL13033265 | 0.78 | SIRT1 (0.49) | SIRT1ALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL356279 | 0.78 | SMN1; SMN2 (0.64) | SIRT1ALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL9071272 | 0.78 | SIRT1 (0.49) | SIRT1ALDH1A1TSHRMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293919-B2 | Antibacterial sulfone and sulfoxide substituted heterocyclic urea compounds | CRESTONE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20100286169-A1 | Antibacterial Sulfone and Sulfoxide Substituted Heterocyclic Urea Compounds | CRESTONE, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| WO-2009015193-A1 | ANTIBACTERIAL SULFONE AND SULFOXIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286169-A1 | Antibacterial Sulfone and Sulfoxide Substituted Heterocyclic Urea Compounds | TST, UMPS, UROD | SIRT1 652/4885ALDH1A1 2644/4885TSHR 3215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.