Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5526919 | 0.85 | HRH3 (0.66) | HRH3HDAC1HDAC2MAPTMMP3 | |
| SCHEMBL12408526 | 0.85 | HRH3 (0.66) | HRH3HDAC1HDAC2MAPTMMP3 | |
| SCHEMBL7983991 | 0.85 | HRH3 (0.66) | HRH3HDAC1HDAC2MAPTMMP3 | |
| SCHEMBL7387284 | 0.85 | HRH3 (0.66) | HRH3HDAC1HDAC2MAPTMMP3 | |
| SCHEMBL1579372 | 0.85 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHTTL3MBTL1 | |
| SCHEMBL3517104 | 0.85 | ALDH1A1 (0.40) | HRH3MAPTALDH1A1HPGDPPARD | |
| SCHEMBL31238634 | 0.85 | PTGDR2 (0.41) | HRH3HDAC1HDAC2MAPTALDH1A1 | |
| SCHEMBL20332712 | 0.83 | HRH3 (0.60) | HRH3HDAC1HDAC2MAPTMMP3 | |
| SCHEMBL20333565 | 0.83 | HRH3 (0.60) | HRH3HDAC1HDAC2MAPTMMP3 | |
| SCHEMBL5519875 | 0.83 | HRH3 (0.62) | HRH3HDAC1HDAC2MAPTMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436049-B2 | Uses of pentamidine and related compounds | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (US) | 2013-05-07 | — | — | US | disclosed |
| US-8436049-B2 | Uses of pentamidine and related compounds | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (US) | 2013-05-07 | — | — | US | disclosed |
| US-8436049-B2 | Uses of pentamidine and related compounds | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (US) | 2013-05-07 | — | — | US | disclosed |
| US-20100323993-A1 | USES OF PENTAMIDINE AND RELATED COMPOUNDS | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON | 2010-12-23 | — | — | US | disclosed |
| US-20100323993-A1 | USES OF PENTAMIDINE AND RELATED COMPOUNDS | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON | 2010-12-23 | — | — | US | disclosed |
| US-20100323993-A1 | USES OF PENTAMIDINE AND RELATED COMPOUNDS | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON | 2010-12-23 | — | — | US | disclosed |
| WO-2009105691-A2 | USES OF PENTAMIDINE AND RELATED COMPOUNDS | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (US) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009105691-A2 | USES OF PENTAMIDINE AND RELATED COMPOUNDS | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (US) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100323993-A1 | USES OF PENTAMIDINE AND RELATED COMPOUNDS | MBNL1, MTPN, RRBP1 | HRH3 2698/4885HDAC1 2269/4885HDAC2 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.