Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 4/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514828 | 0.83 | FEN1 (0.46) | ALDH1A1CNR1CNR2TP53MEN1 | |
| SCHEMBL3517727 | 0.78 | MEN1 (0.57) | ALDH1A1CNR1CNR2TP53MEN1 | |
| SCHEMBL3516175 | 0.77 | CNR2 (0.41) | CNR1CNR2 | |
| SCHEMBL3518030 | 0.77 | FEN1 (0.49) | ALDH1A1CNR1CNR2TP53MEN1 | |
| SCHEMBL3517794 | 0.74 | KDM4E (0.44) | ALDH1A1TACR1MEN1KMT2AKDM4E | |
| SCHEMBL16250051 | 0.74 | FEN1 (0.49) | ALDH1A1CNR1CNR2TP53KDM4E | |
| SCHEMBL3517675 | 0.73 | CNR2 (0.47) | ALDH1A1CNR1CNR2TP53KDM4E | |
| SCHEMBL3514525 | 0.73 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL3517646 | 0.73 | EGFR (0.57) | ALDH1A1CNR1CNR2TP53MEN1 | |
| SCHEMBL3516083 | 0.72 | CNR2 (0.39) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | ALDH1A1 1486/4885APOBEC3A 884/4885CNR1 4017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.