Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 4/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL350994 | 0.88 | ENPP2 (0.44) | PTGDR2ENPP2ATXN2TRPV1 | |
| SCHEMBL543599 | 0.78 | MGLL (0.43) | PTGDR2ENPP2ATXN2MGLL | |
| SCHEMBL542986 | 0.78 | NPSR1 (0.44) | PTGDR2ENPP2ATXN2MGLLALDH1A1 | |
| SCHEMBL351111 | 0.73 | PTGDR2 (0.39) | PTGDR2ENPP2ATXN2TRPV1 | |
| SCHEMBL11226918 | 0.69 | IDO1 (0.46) | PTGDR2MGLLALDH1A1 | |
| SCHEMBL3192328 | 0.69 | PTGDR2 (0.51) | PTGDR2TMEM97SIGMAR1 | |
| SCHEMBL15056650 | 0.68 | PTGDR2 (0.70) | PTGDR2 | |
| SCHEMBL3210652 | 0.67 | PTGDR2 (0.49) | PTGDR2TMEM97SIGMAR1 | |
| SCHEMBL3456263 | 0.67 | GAA (0.34) | GAA | |
| SCHEMBL5072631 | 0.66 | ABHD6 (0.32) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | PTGDR2 1463/4885ENPP2 1/4885ATXN2 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.