Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386134 | 0.85 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL2025252 | 0.82 | LMNA (0.57) | MAPTSMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL2056931 | 0.79 | ALDH1A1 (0.72) | MAPTSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL29670121 | 0.79 | ALDH1A1 (0.72) | MAPTSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4833903 | 0.79 | MAPT (0.54) | MAPTSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL28033469 | 0.77 | L3MBTL1 (0.53) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6387026 | 0.77 | MAPT (0.52) | MAPTSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4396535 | 0.77 | MAPT (0.52) | MAPTSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL11775934 | 0.76 | CYP3A4 (0.53) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL11177962 | 0.74 | HTT (0.58) | MAPTSMN1; SMN2ALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |