Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | FSHR | P23945 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2195627 | 0.89 | NOTUM (0.50) | MEN1ADRB2KMT2ANPSR1NOTUM | |
| SCHEMBL2193665 | 0.84 | FSHR (0.63) | MEN1ADRB2KMT2ANPSR1NOTUM | |
| SCHEMBL10560315 | 0.81 | NOTUM (0.71) | NOTUMBRD4 | |
| SCHEMBL3655121 | 0.81 | FSHR (0.62) | TSHRFSHRTP53MAPT | |
| SCHEMBL3524667 | 0.81 | TSHR (0.49) | MEN1ADRB2KMT2ANPSR1TSHR | |
| SCHEMBL3522467 | 0.77 | FSHR (0.44) | MEN1ADRB2KMT2ANPSR1NOTUM | |
| SCHEMBL17209732 | 0.75 | FSHR (0.53) | NOTUMTSHRFSHRBRD4 | |
| SCHEMBL2196163 | 0.74 | TSHR (0.61) | TSHRFSHRTP53LMNA | |
| SCHEMBL2194582 | 0.74 | FSHR (0.61) | TSHRFSHRMAPT | |
| SCHEMBL2194212 | 0.74 | TSHR (0.61) | TSHRFSHRTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174940-B2 | TSH receptor antagonizing tetrahydroquinoline compounds | MERCK SHARP & DOHME B.V. (NL) | 2015-11-03 | — | — | US | disclosed |
| US-20110172267-A1 | TSH receptor antagonizing tetrahydroquinoline compounds | N.V. ORGANON | 2011-07-14 | — | — | US | disclosed |
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |
| US-20060142334-A1 | Tetrahydroquinoline derivatives | MERCK SHARP & DOHME B.V. (NL) | 2006-06-29 | — | — | US | disclosed |
| EP-1578726-A2 | TETRAHYDROQUINOLINE DERIVATIVES | Akzo Nobel N.V. (NL) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056780-A2 | TETRAHYDROQUINOLINE DERIVATIVES | AKZO NOBEL N.V. (NL) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142334-A1 | Tetrahydroquinoline derivatives | GNRHR, KCNH3, HCAR3 | MEN1 2286/4885ADRB2 602/4885KMT2A 794/4885 |
| US-20110172267-A1 | TSH receptor antagonizing tetrahydroquinoline compounds | TSHR, MC1R, TRHR | MEN1 74/4885ADRB2 279/4885KMT2A 1737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.