Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7770583 | 0.89 | DYRK1A (0.32) | TSHRKCNA5 | |
| SCHEMBL17653626 | 0.81 | MYC (0.35) | — | |
| SCHEMBL5683250 | 0.81 | — | — | |
| SCHEMBL1850398 | 0.80 | — | — | |
| SCHEMBL2257684 | 0.78 | — | — | |
| SCHEMBL5683854 | 0.77 | — | — | |
| SCHEMBL933062 | 0.74 | CHRNA7 (0.47) | — | |
| SCHEMBL695229 | 0.74 | L3MBTL1 (0.39) | — | |
| SCHEMBL8829976 | 0.74 | — | — | |
| SCHEMBL303323 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718201-B1 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2016-09-14 | — | — | EP | disclosed |
| US-20150344509-A1 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2015-12-03 | — | — | US | disclosed |
| US-9096628-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140080797-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2014-03-20 | — | — | US | disclosed |
| US-8618089-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2013-12-31 | — | — | US | disclosed |
| US-20120264725-A1 | SUBSTITUTED PORPHYRINS | BATINIC-HABERLE INES (US) | 2012-10-18 | — | — | US | disclosed |
| US-8183364-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2012-05-22 | — | — | US | disclosed |
| US-20100305083-A1 | SUBSTITUTED PORPHYRINS | BATINIC-HABERLE INES | 2010-12-02 | — | — | US | disclosed |
| US-7807825-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2010-10-05 | — | — | US | disclosed |
| US-20080021007-A1 | Substituted Porphyrins | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-01-24 | — | — | US | disclosed |
| EP-1718201-A1 | SUBSTITUTED PORPHYRINS | Duke University (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077269-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344509-A1 | SUBSTITUTED PORPHYRINS | PPOX, FECH, MB | ADRA1A 4484/4885TSHR 4128/4885KCNA5 2101/4885 |
| US-20120264725-A1 | SUBSTITUTED PORPHYRINS | PPOX, FECH, MB | ADRA1A 4484/4885TSHR 4128/4885KCNA5 2101/4885 |
| US-20080021007-A1 | Substituted Porphyrins | SOD3, SOD1, PRDX3 | ADRA1A 4880/4885TSHR 3915/4885KCNA5 441/4885 |
| US-20140080797-A1 | SUBSTITUTED PORPHYRINS | PPOX, FECH, MB | ADRA1A 4484/4885TSHR 4128/4885KCNA5 2101/4885 |
| US-20100305083-A1 | SUBSTITUTED PORPHYRINS | SOD3, SOD1, PRDX3 | ADRA1A 4872/4885TSHR 3733/4885KCNA5 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.