Sugi Predict

Sugi Predict / Compounds / SCHEMBL3525543

SCHEMBL3525543

SCHEMBL3525543

COC(=O)CCCC#Cc1cc(Cl)ccc1NS(=O)(=O)c1ccc2ncsc2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.44
▸ PKM P14618 1/20 0.44
▸ GLO1 Q04760 1/20 0.41
▸ CCR9 P51686 2/20 0.40
▸ PPARG P37231 1/20 0.40
▸ PPARD Q03181 1/20 0.40
▸ PPARA Q07869 1/20 0.40
▸ CCKBR P32239 1/20 0.40
▸ POLB P06746 2/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.39
▸ AKT1 P31749 1/20 0.39
▸ PIK3CA P42336 1/20 0.39
▸ MTOR P42345 1/20 0.39
▸ CCR2 P41597 1/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ GAA P10253 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3522630 0.95 ALDH1A1 (0.46) ALDH1A1PKMGLO1CCR9PPARG
SCHEMBL3524894 0.88 ALDH1A1 (0.42) ALDH1A1PKMGLO1PPARGPPARD
SCHEMBL3524149 0.86 LMNA (0.47) ALDH1A1PKMPPARGPPARDMEN1
SCHEMBL3528328 0.85 TSHR (0.41) ALDH1A1CCR9PPARGCCKBRCCR2
SCHEMBL3529515 0.85 PPARG (0.42) ALDH1A1PKMCCR9PPARGPPARD
SCHEMBL3524989 0.83 AKT1 (0.50) RXFP1AKT1PIK3CAMTORGAA
SCHEMBL3525396 0.83 ALDH1A1 (0.44) ALDH1A1PKMGLO1PPARGPPARD
SCHEMBL3528051 0.83 ALDH1A1 (0.45) ALDH1A1PKMCCR9PPARGPPARD
SCHEMBL3523608 0.82 ALDH1A1 (0.43) ALDH1A1PKMGLO1PPARGPPARD
SCHEMBL3523854 0.82 ALDH1A1 (0.43) ALDH1A1PKMGLO1CCR9PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109316601-B Pharmaceutical composition and use thereof 武汉朗来科技发展有限公司 2021-11-09 — — CN disclosed
US-8436040-B2 Method of treating conditions involving PPAR-receptors with indole compounds LABORATOIRES FOURNIER S.A. (FR) 2013-05-07 — — US disclosed
US-20100286137-A1 Method of Treating Conditions Involving PPAR-Receptors with Indole Compounds LABORATORIES FOURNIER S.A. (FR) 2010-11-11 — — US disclosed
US-7795297-B2 Indole compounds, method of preparing them and uses thereof LABORATORIES FOURNIER S.A. (FR) 2010-09-14 — — US disclosed
US-20080153816-A1 Indole Compounds, Method of Preparing Them and Uses Thereof LABORATOIRES FOURNIER S.A. (FR) 2008-06-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153816-A1 Indole Compounds, Method of Preparing Them and Uses Thereof LIPG, GPR119, IAPP ALDH1A1 1607/4885PKM 728/4885GLO1 311/4885
US-20100286137-A1 Method of Treating Conditions Involving PPAR-Receptors with Indole Compounds GPR119, PPARA, PPARG ALDH1A1 1453/4885PKM 747/4885GLO1 1071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.