Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FSHR | P23945 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529784 | 0.73 | FSHR (0.48) | FSHRLRRK2MEN1KMT2A | |
| SCHEMBL4217129 | 0.63 | AKR1C2 (0.54) | PTGESAKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL6353185 | 0.63 | AKR1C2 (0.72) | LMNAGPR132AKR1C2AKR1C1MEN1 | |
| SCHEMBL1322915 | 0.61 | FSHR (0.69) | FSHRMEN1KMT2A | |
| SCHEMBL3527025 | 0.61 | FSHR (0.56) | FSHRMEN1KMT2A | |
| SCHEMBL4373972 | 0.60 | MAPT (0.36) | POLBLMNAAKR1C2AKR1C1KMT2A | |
| SCHEMBL6821934 | 0.59 | AKR1C2 (0.53) | PTGESLRRK2AKR1C2AKR1C1MEN1 | |
| SCHEMBL1714879 | 0.59 | CDC7 (0.47) | POLBLMNALRRK2MEN1KMT2A | |
| SCHEMBL6818679 | 0.59 | ALDH1A1 (0.52) | POLBLMNAPTGESLRRK2AKR1C2 | |
| SCHEMBL4369531 | 0.59 | FSHR (0.58) | FSHRMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| US-20060142334-A1 | Tetrahydroquinoline derivatives | MERCK SHARP & DOHME B.V. (NL) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142334-A1 | Tetrahydroquinoline derivatives | GNRHR, KCNH3, HCAR3 | FSHR 9/4885POLB 3243/4885LMNA 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.