Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28530907 | 0.83 | ALDH1A1 (0.51) | STAT3ALDH1A1KDM4EGAAGLA | |
| SCHEMBL1323012 | 0.83 | APEX1 (0.58) | ALDH1A1KDM4EGLAMAPTMEN1 | |
| SCHEMBL21666210 | 0.81 | ALDH1A1 (0.64) | STAT3ALDH1A1KDM4EGAAGLA | |
| SCHEMBL21198945 | 0.80 | ALDH1A1 (0.60) | STAT3ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL21199639 | 0.80 | ALDH1A1 (0.45) | STAT3ALDH1A1KDM4EGAAGLA | |
| SCHEMBL23615720 | 0.76 | STAT3 (0.47) | STAT3ALDH1A1KDM4EGAAGLA | |
| SCHEMBL13753947 | 0.76 | HPGD (0.44) | STAT3ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL31173096 | 0.76 | HPGD (0.50) | ALDH1A1KDM4EGAAGLAMAPT | |
| SCHEMBL21453742 | 0.76 | ALDH1A1 (0.44) | STAT3ALDH1A1KDM4EGAAGLA | |
| SCHEMBL25014735 | 0.76 | ALDH1A1 (0.44) | STAT3ALDH1A1KDM4EGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |
| CN-100404508-C | Tetrahydroquinoline derivatives | AKZO NOBEL NV (NL) | 2008-07-23 | — | — | CN | disclosed |
| US-20060142334-A1 | Tetrahydroquinoline derivatives | MERCK SHARP & DOHME B.V. (NL) | 2006-06-29 | — | — | US | disclosed |
| CN-1729175-A | Tetrahydroquinoline derivatives | AKZO NOBEL NV (NL) | 2006-02-01 | — | — | CN | disclosed |
| EP-1578726-A2 | TETRAHYDROQUINOLINE DERIVATIVES | Akzo Nobel N.V. (NL) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056780-A2 | TETRAHYDROQUINOLINE DERIVATIVES | AKZO NOBEL N.V. (NL) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142334-A1 | Tetrahydroquinoline derivatives | GNRHR, KCNH3, HCAR3 | STAT3 1095/4885ALDH1A1 1133/4885KDM4E 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.