Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531503 | 0.85 | ABCB1 (0.36) | HTR6ABCB1ADORA3ADORA2AADORA1 | |
| SCHEMBL3535823 | 0.84 | HTR6 (0.50) | HTR1BHTR6TDP1 | |
| SCHEMBL3528627 | 0.83 | TDP1 (0.47) | HTR6TDP1 | |
| SCHEMBL3531571 | 0.83 | HTR6 (0.42) | HTR1BHTR6ABCB1 | |
| SCHEMBL3531498 | 0.83 | HTR1B (0.48) | HTR1BHTR6 | |
| SCHEMBL3529159 | 0.79 | HTR1B (0.48) | HTR1BHTR6 | |
| SCHEMBL3532573 | 0.78 | MAPT (0.41) | HTR6 | |
| SCHEMBL3532007 | 0.78 | MAPT (0.40) | HTR6F2 | |
| SCHEMBL3539703 | 0.75 | MAPT (0.41) | HTR1BHTR6 | |
| SCHEMBL3535014 | 0.72 | HTR6 (0.45) | HTR1BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |