Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532573 | 0.99 | MAPT (0.41) | MAPTTP53HTR6BCHEALDH1A1 | |
| SCHEMBL3539703 | 0.96 | MAPT (0.41) | MAPTTP53HTR6BCHEALDH1A1 | |
| SCHEMBL3529593 | 0.88 | HTR6 (0.44) | HTR6ALDH1A1KDM4EHTR2AHTR2C | |
| SCHEMBL3532575 | 0.86 | TP53 (0.41) | MAPTTP53HTR6BCHEALDH1A1 | |
| SCHEMBL3539699 | 0.86 | HTR6 (0.45) | MAPTTP53HTR6BCHEALDH1A1 | |
| SCHEMBL3535899 | 0.85 | TP53 (0.43) | MAPTTP53HTR6BCHEALDH1A1 | |
| SCHEMBL3532453 | 0.85 | LTA4H (0.44) | HTR6ALDH1A1KDM4EHTR7 | |
| SCHEMBL3532484 | 0.85 | HTR6 (0.44) | HTR6ALDH1A1KDM4EHTR2AHTR2C | |
| SCHEMBL3532568 | 0.84 | HTR6 (0.47) | MAPTTP53HTR6BCHEPTGER4 | |
| SCHEMBL3532004 | 0.84 | HTR6 (0.46) | MAPTTP53HTR6BCHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |