Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531502 | 0.85 | HASPIN (0.39) | ABCB1HTR6ADORA3ADORA2AADORA1 | |
| SCHEMBL3535823 | 0.83 | HTR6 (0.50) | HTR6HTR3A | |
| SCHEMBL3528627 | 0.82 | TDP1 (0.47) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL3531498 | 0.81 | HTR1B (0.48) | HTR6 | |
| SCHEMBL3531571 | 0.81 | HTR6 (0.42) | ABCB1HTR6DRD2 | |
| SCHEMBL3532575 | 0.80 | TP53 (0.41) | HTR6HTR1AHTR7DRD2 | |
| SCHEMBL3529159 | 0.73 | HTR1B (0.48) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL3535014 | 0.71 | HTR6 (0.45) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL3532009 | 0.71 | TP53 (0.40) | HTR6 | |
| SCHEMBL3534202 | 0.70 | TDP1 (0.48) | HTR6HTR1AHTR7DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |