Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3538879 | 0.87 | HTR1B (0.47) | HTR6KDM4EHTR1BALDH1A1HTR1D | |
| SCHEMBL3531498 | 0.83 | HTR1B (0.48) | HTR6HTR1B | |
| SCHEMBL3535823 | 0.83 | HTR6 (0.50) | HTR6KDM4EHTR1BALDH1A1LMNA | |
| SCHEMBL3531502 | 0.83 | HASPIN (0.39) | HTR6HTR1BABCB1 | |
| SCHEMBL3528627 | 0.82 | TDP1 (0.47) | HTR6KDM4EDRD2DRD1DRD3 | |
| SCHEMBL3535899 | 0.81 | TP53 (0.43) | HTR6KDM4EHTR1BALDH1A1LMNA | |
| SCHEMBL3531503 | 0.81 | ABCB1 (0.36) | HTR6DRD2ABCB1 | |
| SCHEMBL3534079 | 0.78 | HTR1B (0.43) | HTR6KDM4EHTR1BALDH1A1LMNA | |
| SCHEMBL3532652 | 0.76 | HTR1B (0.52) | HTR6HTR1BHTR1DDRD2DRD3 | |
| SCHEMBL3529159 | 0.71 | HTR1B (0.48) | HTR6HTR1BHTR1DDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |