Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532575 | 0.91 | TP53 (0.41) | TP53MAPTHTR6BCHEFFAR2 | |
| SCHEMBL3539703 | 0.85 | MAPT (0.41) | TP53MAPTHTR6BCHEFFAR2 | |
| SCHEMBL3535899 | 0.85 | TP53 (0.43) | TP53MAPTHTR6BCHEFFAR2 | |
| SCHEMBL3532573 | 0.85 | MAPT (0.41) | TP53MAPTHTR6BCHEFFAR2 | |
| SCHEMBL3532568 | 0.84 | HTR6 (0.47) | TP53MAPTHTR6BCHEPTGER4 | |
| SCHEMBL3532007 | 0.84 | MAPT (0.40) | TP53MAPTHTR6BCHEFFAR2 | |
| SCHEMBL3539699 | 0.84 | HTR6 (0.45) | TP53MAPTHTR6BCHEALDH1A1 | |
| SCHEMBL3532004 | 0.84 | HTR6 (0.46) | TP53MAPTHTR6BCHEKMT2A | |
| SCHEMBL3532453 | 0.81 | LTA4H (0.44) | HTR6ALDH1A1KDM4E | |
| SCHEMBL3529596 | 0.80 | HTR6 (0.44) | HTR6MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |