Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533742 | 0.89 | HTR6 (0.44) | SLC6A9DRD2HTR6AGERHTR1D | |
| SCHEMBL3532568 | 0.87 | HTR6 (0.47) | TP53MAPTHTR6BCHEHTR1B | |
| SCHEMBL3539699 | 0.87 | HTR6 (0.45) | TP53MAPTHTR6BCHEKDM4E | |
| SCHEMBL3539703 | 0.86 | MAPT (0.41) | TP53MAPTHTR6BCHEMAPK1 | |
| SCHEMBL3532573 | 0.86 | MAPT (0.41) | TP53MAPTHTR6BCHEMAPK1 | |
| SCHEMBL3532575 | 0.85 | TP53 (0.41) | TP53MAPTDRD2HTR6BCHE | |
| SCHEMBL3532007 | 0.85 | MAPT (0.40) | TP53MAPTHTR6BCHEMAPK1 | |
| SCHEMBL3532004 | 0.85 | HTR6 (0.46) | TP53MAPTDRD2HTR6BCHE | |
| SCHEMBL3532009 | 0.85 | TP53 (0.40) | TP53MAPTHTR6BCHEMAPK1 | |
| SCHEMBL3531635 | 0.85 | HTR6 (0.44) | DRD2HTR6HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |