Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532568 | 0.93 | HTR6 (0.47) | HTR6BCHEHTR1AADRA1DADRA1A | |
| SCHEMBL3539699 | 0.89 | HTR6 (0.45) | HTR6BCHEHTR1AADRA1DADRA1A | |
| SCHEMBL3529169 | 0.89 | HTR6 (0.43) | HTR6BCHEKMT2AHTR1AADRA1D | |
| SCHEMBL3539703 | 0.85 | MAPT (0.41) | HTR6BCHEKMT2ATP53MAPT | |
| SCHEMBL3535899 | 0.85 | TP53 (0.43) | HTR6BCHETP53MAPTKDM4E | |
| SCHEMBL3532573 | 0.85 | MAPT (0.41) | HTR6BCHEKMT2ATP53MAPT | |
| SCHEMBL3532007 | 0.84 | MAPT (0.40) | HTR6BCHEKMT2ATP53MAPT | |
| SCHEMBL3532009 | 0.84 | TP53 (0.40) | HTR6BCHEKMT2ATP53MAPT | |
| SCHEMBL3532575 | 0.82 | TP53 (0.41) | HTR6BCHEKMT2AHTR1ATP53 | |
| SCHEMBL3529592 | 0.82 | HTR1B (0.44) | HTR6BCHEHTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |