Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531880 | 0.87 | L3MBTL1 (0.47) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3530205 | 0.84 | MAPT (0.49) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3531695 | 0.83 | KDR (0.46) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3528455 | 0.79 | POLB (0.41) | MAPK10MEN1KMT2AMAPK1TMPRSS2 | |
| SCHEMBL3529720 | 0.76 | L3MBTL1 (0.54) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3529721 | 0.76 | L3MBTL1 (0.58) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3536349 | 0.76 | ENPP2 (0.59) | TMPRSS2LMNAPOLBENPP2 | |
| SCHEMBL3533559 | 0.71 | PPARG (0.47) | L3MBTL1CNR1MAPTTP53 | |
| SCHEMBL3530236 | 0.70 | NTRK1 (0.39) | MAPTENPP2TP53 | |
| SCHEMBL3531008 | 0.69 | KDR (0.47) | CYP1A2CYP2C9CYP2C19MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662828-B2 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds | GRUENENTHAL GMBH (DE) | 2010-02-16 | — | — | US | claimed |