Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 8/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.50 |
| ▸ | FER | P16591 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | MARK3 | P27448 | 2/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.50 |
| ▸ | STK3 | Q13188 | 2/20 | 0.50 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.50 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534395 | 0.84 | PDPK1 (0.72) | PDPK1FGFR1FLT3CLK4MAP4K4 | |
| SCHEMBL3538485 | 0.84 | PDPK1 (0.51) | PDPK1FGFR1FLT3CLK4FLT1 | |
| SCHEMBL3537735 | 0.84 | PDPK1 (1.00) | PDPK1FGFR1FLT3CLK4MAP4K4 | |
| SCHEMBL3532319 | 0.82 | PDPK1 (0.51) | PDPK1FGFR1FLT3CLK4MAP4K4 | |
| SCHEMBL3531870 | 0.81 | PDPK1 (0.71) | PDPK1FGFR1FLT3CLK4MAP4K4 | |
| SCHEMBL5951751 | 0.81 | PDPK1 (0.80) | PDPK1FGFR1FLT3CLK4MAP4K4 | |
| SCHEMBL3542692 | 0.81 | PDPK1 (0.56) | PDPK1FGFR1FLT3CLK4MAP4K4 | |
| SCHEMBL5951667 | 0.80 | MAP3K8 (0.51) | PDPK1FGFR1FLT3CLK4MAP4K4 | |
| SCHEMBL3534190 | 0.79 | MAPT (0.55) | PDPK1FGFR1FLT1AMY1APKN2 | |
| SCHEMBL3539728 | 0.76 | KDM4E (0.58) | PDPK1FGFR1FLT3CLK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |
| US-20060079564-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079564-A1 | Indazole benzimidazole compounds | ABL1, ABL2, ALK | PDPK1 1862/4885FGFR1 886/4885FLT3 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.