Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3288493 | 0.86 | RBP4 (0.41) | DGAT2TRPA1TRPV1POLBACHE | |
| SCHEMBL3533104 | 0.83 | TRPA1 (0.43) | DGAT2TRPA1TRPV1POLBACHE | |
| SCHEMBL3288655 | 0.82 | P2RX7 (0.54) | MEN1KMT2A | |
| SCHEMBL3290531 | 0.82 | P2RX7 (0.54) | MEN1KMT2A | |
| SCHEMBL3288758 | 0.82 | P2RX7 (0.53) | MEN1KMT2A | |
| SCHEMBL2421627 | 0.77 | TRPA1 (0.68) | TRPA1TRPV1POLBKCNH2TRPM8 | |
| SCHEMBL3535170 | 0.77 | P2RX7 (0.53) | — | |
| SCHEMBL3292797 | 0.76 | MEN1 (0.46) | MEN1KMT2A | |
| SCHEMBL31652019 | 0.76 | POLB (0.55) | TRPA1TRPV1POLBACHE | |
| SCHEMBL11366665 | 0.75 | POLB (0.54) | TRPA1TRPV1POLBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704997-B1 | Amino-tetrazole analogues and methods of use | ABBOTT LABORATORIES (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060052374-A1 | Amino-tetrazole analogues and methods of use | ABBVIE INC. | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052374-A1 | Amino-tetrazole analogues and methods of use | P2RX7, P2RX2, P2RX3 | DGAT2 4589/4885TRPA1 109/4885TRPV1 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.