Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 6/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532185 | 0.85 | HTR6 (0.45) | PDE3BPDE3AP2RY12HDAC3HDAC4 | |
| SCHEMBL3533173 | 0.84 | OPRD1 (0.39) | OPRD1PDE3BPDE3AP2RY12HDAC3 | |
| SCHEMBL3530480 | 0.83 | HTR6 (0.39) | OPRD1PDE3BPDE3AP2RY12HDAC3 | |
| SCHEMBL3535203 | 0.82 | FGFR1 (0.44) | PDE3BPDE3AP2RY12HDAC3HDAC4 | |
| SCHEMBL3533707 | 0.81 | HTR6 (0.40) | OPRD1PDE3BPDE3AP2RY12HDAC3 | |
| SCHEMBL3536803 | 0.81 | KDM4E (0.50) | HTR6POLBL3MBTL1 | |
| SCHEMBL3534708 | 0.79 | HTR6 (0.45) | CYP1A2CYP2C9CYP2C19HTR6CYP2D6 | |
| SCHEMBL3536219 | 0.79 | ALDH1A1 (0.42) | PDE3BPDE3AP2RY12HTR6 | |
| SCHEMBL3531385 | 0.78 | CHRNB2 (0.42) | PDE3BPDE3AP2RY12HTR6POLB | |
| SCHEMBL3534825 | 0.78 | MAOB (0.43) | OPRD1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |