Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Methionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 10/20 | 0.44 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | GRM8 | O00222 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racemethionine SCHEMBL353437 | 1.00 | BHMT (0.44) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Lysine SCHEMBL28084777 | 0.89 | GSR (0.53) | BHMTBHMT2NOS2NOS3NOS1 | |
| Hexamethonium SCHEMBL21682526 | 0.87 | BHMT (0.45) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL6230721 | 0.87 | BHMT (0.35) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL28066527 | 0.86 | BHMT (0.52) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Methionine SCHEMBL28066526 | 0.86 | BHMT (0.52) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL28793490 | 0.86 | BHMT (0.52) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Methionine SCHEMBL29385886 | 0.86 | BHMT (0.55) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Methionine SCHEMBL1376293 | 0.86 | BHMT (0.55) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL94187 | 0.86 | BHMT (0.55) | BHMTBHMT2RNPEPNOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 519 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119530369-A | Fatty liver detection kit development system | 安徽省德济堂药业有限公司 | 2025-02-28 | — | — | CN | claimed |
| CN-118844382-A | Construction method of young rabbit model of acute pneumonia | 河南省儿童医院郑州儿童医院 | 2024-10-29 | — | — | CN | claimed |
| CN-118090946-A | Detection method for measuring choline bitartrate and methionine in compound choline methionine tablet | 通化东宝药业股份有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-117530957-A | Application of ammonium tetrathiomolybdate in preparation of medicines for treating metabolic-related fatty liver diseases | 首都医科大学 | 2024-02-09 | — | — | CN | claimed |
| CN-116068090-A | Energy efficiency color band-based compound wood chicken granule anti-hepatitis quality evaluation method | 丹东药业集团有限公司 | 2023-05-05 | — | — | CN | claimed |
| US-11154567-B2 | Method for treating liver disease with kinsenoside | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-10-26 | — | — | US | claimed |
| CN-112626197-A | Preparation method of lncRNA marker of non-alcoholic steatohepatitis | 南京师范大学常州创新发展研究院 | 2021-04-09 | — | — | CN | claimed |
| CN-112522383-A | Preparation method of miRNA marker of non-alcoholic steatohepatitis | 南京师范大学常州创新发展研究院 | 2021-03-19 | — | — | CN | claimed |
| CN-108794652-B | Chitin integrated production system and processing method thereof | 中国科学院过程工程研究所 | 2021-02-05 | — | — | CN | claimed |
| CN-111012789-A | Application of amygdalin in preparing medicine for treating fatty liver disease | 上海中医药大学附属曙光医院 | 2020-04-17 | — | — | CN | claimed |
| CN-108794652-A | A kind of chitin integraterd manufacturing system and its processing method | 中国科学院过程工程研究所 | 2018-11-13 | — | — | CN | claimed |
| CN-108743914-A | Val-Val-Tyr-Pro or its salt are preparing the application in preventing or treating non-alcohol fatty liver drug | 江西本草天工科技有限责任公司 | 2018-11-06 | — | — | CN | claimed |
| CN-108669345-A | A kind of broiler fodder reducing rate of falling ill | 无为县春平养殖专业合作社 | 2018-10-19 | — | — | CN | claimed |
| CN-107821755-A | A kind of young chicken feed | 无为县龙口花卉苗木有限公司 | 2018-03-23 | — | — | CN | claimed |
| CN-107778347-A | It is a kind of using amino acid ion liquid from silkworm chrysalis separated and dissolved pupa albumen method | 中国科学院过程工程研究所 | 2018-03-09 | — | — | CN | claimed |
| CN-107312109-A | Chitin separating and extracting process in a kind of shrimp and crab shells based on degradable ionic liquid | 中国科学院过程工程研究所 | 2017-11-03 | — | — | CN | claimed |
| CN-116983261-B | Choline amino acid ionic liquid microemulsion, and preparation method and application thereof | NORTHEASTERN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | disclosed |
| CN-122056902-A | Pharmaceutical application of harpagoside | 金陵药业股份有限公司 | 2026-05-19 | — | — | CN | disclosed |
| EP-0596026-A1 | ANTIBIOTIC FEED COMPOSITIONS AND METHOD OF ENHANCING FEED EFFICIENCY AND PROMOTING GROWTH IN MONOGASTIC ANIMALS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-11 | — | — | EP | disclosed |
| WO-1993001829-A1 | ANTIBIOTIC FEED COMPOSITIONS AND METHOD OF ENHANCING FEED EFFICIENCY AND PROMOTING GROWTH IN MONOGASTIC ANIMALS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11154567-B2 | Method for treating liver disease with kinsenoside | OAT, SLC10A1, GYS2 | BHMT 427/4885BHMT2 348/4885RNPEP 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.