Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | UNG | P13051 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.38 |
| ▸ | ABAT | P80404 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21310006 | 0.81 | UNG (0.42) | ALDH1A1TSHRTDP1NPC1RAB9A | |
| SCHEMBL2048449 | 0.80 | PTGS2 (0.44) | ALDH1A1TDP1NPC1RAB9AUNG | |
| SCHEMBL663468 | 0.79 | MAOA (0.41) | ALDH1A1TSHRTDP1NPC1RAB9A | |
| SCHEMBL17864868 | 0.79 | HDAC4 (0.38) | — | |
| SCHEMBL30291836 | 0.78 | TYR (0.56) | ALDH1A1TDP1UNGSRCMAOA | |
| SCHEMBL727874 | 0.78 | TYR (0.56) | ALDH1A1TDP1UNGSRCMAOA | |
| SCHEMBL8572430 | 0.76 | NPSR1 (0.53) | ALDH1A1TDP1HPGDPOLBTTR | |
| SCHEMBL8572429 | 0.76 | NPSR1 (0.53) | ALDH1A1TDP1HPGDPOLBTTR | |
| Isophthalic Dicarboxaldehyde SCHEMBL3536987 | 0.76 | ALDH1A1 (0.47) | ALDH1A1TSHRTDP1NPC1RAB9A | |
| SCHEMBL3868897 | 0.75 | TYR (0.58) | ALDH1A1TSHRTDP1MAOBCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051327-B2 | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases | ABBVIE INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20140296220-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | ABBVIE INC (US) | 2014-10-02 | — | — | US | disclosed |
| US-8796289-B2 | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| WO-2013013031-A1 | PYRIDAZINO [4, 5 -D] PYRIMIDIN- (6H) -ONE INHIBITORS OF WEE - 1 KINASE | ABBVIE INC. (US) | 2013-01-24 | — | — | WO | disclosed |
| US-20130023523-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2013-01-24 | — | — | US | disclosed |
| US-7687545-B2 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them | INDENA S.P.A. (IT) | 2010-03-30 | — | — | US | disclosed |
| US-20080269292-A1 | N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | INDENA S.P.A. (IT) | 2008-10-30 | — | — | US | disclosed |
| EP-0563715-B1 | Oxyalkynes, pharmaceutical compositions containing same as well as a process for the preparation of these compounds and pharmaceutical compositions | GRUENENTHAL GMBH (DE) | 1996-08-14 | — | — | EP | disclosed |
| EP-0563715-A2 | Oxyalkynes, pharmaceutical compositions containing same as well as a process for the preparation of these compounds and pharmaceutical compositions | Grünenthal GmbH (DE) | 1993-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296220-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | WEE1, WEE2, CDK1 | ALDH1A1 1308/4885TSHR 2309/4885TDP1 640/4885 |
| US-20080269292-A1 | N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | C9, CCNT2, CCNT1 | ALDH1A1 2076/4885TSHR 2895/4885TDP1 1365/4885 |
| US-20130023523-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | WEE1, WEE2, CDK1 | ALDH1A1 1308/4885TSHR 2309/4885TDP1 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.