Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353790 | 0.86 | HDAC1 (0.51) | MAPTSMN1; SMN2TP53HDAC1HDAC6 | |
| SCHEMBL13036112 | 0.84 | KMT2A (0.52) | NPC1MAPTSMN1; SMN2THRBNPSR1 | |
| SCHEMBL353722 | 0.84 | HDAC1 (0.46) | MAPTSMN1; SMN2THRBTP53RXFP1 | |
| SCHEMBL354757 | 0.83 | FABP4 (0.57) | NPC1MAPTSMN1; SMN2THRBNPSR1 | |
| SCHEMBL357128 | 0.81 | HDAC1 (0.41) | MAPTSMN1; SMN2THRBTP53RXFP1 | |
| SCHEMBL354525 | 0.78 | HSD17B10 (0.40) | SMN1; SMN2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL6152416 | 0.75 | MAPT (0.51) | NPC1MAPTSMN1; SMN2THRBNPSR1 | |
| SCHEMBL14160797 | 0.73 | NPC1 (0.68) | NPC1MAPTSMN1; SMN2THRBNPSR1 | |
| SCHEMBL951235 | 0.73 | MEN1 (0.35) | MAPTSMN1; SMN2KDM4EMEN1USP2 | |
| SCHEMBL357129 | 0.71 | FABP4 (0.51) | MAPTSMN1; SMN2TP53HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8334387-B2 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2012-12-18 | — | — | US | disclosed |
| US-8334387-B2 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2012-12-18 | — | — | US | disclosed |
| US-20120015373-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | GE HEALTHCARE UK LIMITED (GB) | 2012-01-19 | — | — | US | disclosed |
| US-20120015373-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | GE HEALTHCARE UK LIMITED (GB) | 2012-01-19 | — | — | US | disclosed |
| US-8034558-B2 | Incubating dye of given formula with biological material, measuring fluorescence lifetime; lectins/glycoproteins, biotin/streptavidin, DNA/RNA | GE HEALTHCARE UK LIMITED (GB) | 2011-10-11 | — | — | US | disclosed |
| US-8034558-B2 | Incubating dye of given formula with biological material, measuring fluorescence lifetime; lectins/glycoproteins, biotin/streptavidin, DNA/RNA | GE HEALTHCARE UK LIMITED (GB) | 2011-10-11 | — | — | US | disclosed |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2011-01-20 | — | — | US | disclosed |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2011-01-20 | — | — | US | disclosed |
| US-20100184098-A1 | METHODS FOR MEASURING ENZYME ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2010-07-22 | — | — | US | disclosed |
| US-20100184098-A1 | METHODS FOR MEASURING ENZYME ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2010-07-22 | — | — | US | disclosed |
| US-7727739-B2 | Methods for measuring enzyme activity | GE HEALTHCARE UK LIMITED (GB) | 2010-06-01 | — | — | US | disclosed |
| US-7727739-B2 | Methods for measuring enzyme activity | GE HEALTHCARE UK LIMITED (GB) | 2010-06-01 | — | — | US | disclosed |
| US-20080139788-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | GE HEALTHCARE UK LIMITED (GB) | 2008-06-12 | — | — | US | disclosed |
| US-20080139788-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | GE HEALTHCARE UK LIMITED (GB) | 2008-06-12 | — | — | US | disclosed |
| US-20070184429-A1 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070184429-A1 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| EP-1497453-B1 | METHODS FOR MEASURING PROTEIN KINASE AND PHOSPHATASE ACTIVITY | GE HEALTHCARE UK LTD (GB) | 2007-06-13 | — | — | EP | disclosed |
| US-7125682-B2 | Methods for measuring protein kinase and phosphatase activity | GE HEALTHCARE UK LIMITED (GB) | 2006-10-24 | — | — | US | disclosed |
| US-20040191792-A1 | Acridone derivatives as labels for fluorescence detection of target materials | GE HEALTHCARE UK LIMITED (GB) | 2004-09-30 | — | — | US | disclosed |
| US-20030228646-A1 | Methods for measuring protein kinase and phosphatase activity | TTP LABTECH LIMITED (GB) | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139788-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | ACR, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ARSA | NPC1 3924/4885MAPT 4659/4885SMN1; SMN2 4300/4885 |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | CYP19A1, CYP17A1, CYP21A2 | NPC1 3129/4885MAPT 4572/4885SMN1; SMN2 4541/4885 |
| US-20040191792-A1 | Acridone derivatives as labels for fluorescence detection of target materials | ACR, ARSA, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | NPC1 3978/4885MAPT 4679/4885SMN1; SMN2 4194/4885 |
| US-20070184429-A1 | Method for measuring aromatase activity | CYP19A1, CYP17A1, CYP21A2 | NPC1 3129/4885MAPT 4572/4885SMN1; SMN2 4541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.