Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513248 | 0.75 | SLC6A2 (0.42) | SIGMAR1KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6946652 | 0.73 | SIGMAR1 (0.55) | SIGMAR1KDM1AMAOAMAOBPIN1 | |
| SCHEMBL4590131 | 0.72 | KMT2A (0.56) | ACHEBRD4 | |
| SCHEMBL1513240 | 0.71 | SLC6A2 (0.44) | SIGMAR1KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12165075 | 0.70 | CTSD (0.37) | SLC6A2SLC6A4SLC6A3PDE1B | |
| SCHEMBL2782958 | 0.67 | OPRM1 (0.50) | SIGMAR1ALDH1A1 | |
| SCHEMBL4588940 | 0.67 | CBX7 (0.45) | MAOBACHE | |
| SCHEMBL7171860 | 0.65 | PDK2 (0.43) | SIGMAR1CYP2C19CYP3A4 | |
| SCHEMBL6300172 | 0.64 | SIGMAR1 (0.46) | SIGMAR1KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11633525 | 0.64 | SIGMAR1 (0.41) | SIGMAR1ALDH1A1BRD4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662956-B2 | Tetrahydrobenzo[d]azepin-2-one derivatives and the use thereof for treating cardiovascular diseases | BAYER SHERING PHARMA AG (DE) | 2010-02-16 | — | — | US | disclosed |
| US-7662956-B2 | Tetrahydrobenzo[d]azepin-2-one derivatives and the use thereof for treating cardiovascular diseases | BAYER SHERING PHARMA AG (DE) | 2010-02-16 | — | — | US | disclosed |
| US-7662956-B2 | Tetrahydrobenzo[d]azepin-2-one derivatives and the use thereof for treating cardiovascular diseases | BAYER SHERING PHARMA AG (DE) | 2010-02-16 | — | — | US | disclosed |
| EP-1716118-B1 | TETRAHYDROBENZO[D]AZEPIN-2- ONE DERIVATIVES AND THE USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2008-04-30 | — | — | EP | disclosed |
| EP-1716118-B1 | TETRAHYDROBENZO[D]AZEPIN-2- ONE DERIVATIVES AND THE USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2008-04-30 | — | — | EP | disclosed |
| US-20070287698-A1 | Tetrahydrobenzo(D)Azepin-2-One Derivatives and the Use Thereof for Treating Cardiovascular Diseases | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | US | disclosed |
| US-20070287698-A1 | Tetrahydrobenzo(D)Azepin-2-One Derivatives and the Use Thereof for Treating Cardiovascular Diseases | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | US | disclosed |
| US-20070287698-A1 | Tetrahydrobenzo(D)Azepin-2-One Derivatives and the Use Thereof for Treating Cardiovascular Diseases | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | US | disclosed |
| EP-1716118-A1 | TETRAHYDROBENZO[D]AZEPIN-2- ONE DERIVATIVES AND THE USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005077907-A1 | TETRAHYDROBENZO[D]AZEPIN-2- ONE DERIVATIVES AND THE USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287698-A1 | Tetrahydrobenzo(D)Azepin-2-One Derivatives and the Use Thereof for Treating Cardiovascular Diseases | APOB, PCSK9, BDKRB1 | SIGMAR1 4337/4885KDM1A 3031/4885MAOA 1756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.