SCHEMBL354359

SCHEMBL354359

O=C(CBr)C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.49
TSHR P16473 2/20 0.49
GLA P06280 1/20 0.42
HSP90AA1 P07900 1/20 0.42
HSD11B1 P28845 4/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
LMNA P02545 1/20 0.42
KDM4E B2RXH2 1/20 0.41
HTT P42858 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22834639 0.90
SCHEMBL4474354 0.82 ALDH1A1 (0.47) ALDH1A1TSHRGLAHSP90AA1HSD11B1
SCHEMBL25568411 0.80 ALDH1A1 (0.52) ALDH1A1TSHRGLAHSP90AA1HSD11B1
SCHEMBL2533725 0.76 ALDH1A1 (0.49) ALDH1A1TSHRHSP90AA1HSD11B1L3MBTL1
SCHEMBL1072478 0.76 ALDH1A1 (0.50) ALDH1A1TSHRGLAHSP90AA1HSD11B1
SCHEMBL14341893 0.76 ALDH1A1 (0.46) ALDH1A1TSHRHSP90AA1HSD11B1L3MBTL1
SCHEMBL11760004 0.76 ALDH1A1 (0.46) ALDH1A1TSHRHSP90AA1HSD11B1L3MBTL1
SCHEMBL1075076 0.74 ALDH1A1 (0.49) ALDH1A1TSHRHSD11B1LMNAKDM4E
SCHEMBL10775431 0.74 ALDH1A1 (0.66) ALDH1A1TSHRGLAHSP90AA1HSD11B1
SCHEMBL3322713 0.74 HTT (0.53) ALDH1A1TSHRGLAHSP90AA1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 222 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104840975-B A kind of super-molecule assembling body and preparation method of targeted delivery siRNA 南开大学 2018-01-23 CN claimed
US-8703194-B2 Stimulus-responsive biodegradable polymers and methods of preparation AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2014-04-22 US claimed
US-8658209-B2 2014-02-25 US claimed
US-20090123544-A1 STIMULUS-RESPONSIVE BIODEGRADABLE POLYMERS AND METHODS OF PREPARATION AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH 2009-05-14 US claimed
US-6797745-B1 Hot melt inks containing styrene or terpene polymers XEROX CORPORATION 2004-09-28 US claimed
CN-112368640-B Actinic-ray-or radiation-sensitive resin composition, resist film, pattern forming method, and method for manufacturing electronic device 富士胶片株式会社 2025-02-07 CN disclosed
US-12216404-B2 Actinic ray-sensitive or radiation-sensitive resin composition, resist film, pattern forming method, and method for manufacturing electronic device FUJIFILM CORPORATION (JP) 2025-02-04 US disclosed
WO-2023020486-A1 RIP1 KINASE INHIBITOR COMPOUND AND COMPOSITION AND USE THEREOF 广州市恒诺康医药科技有限公司 2023-02-23 WO disclosed
US-11584742-B2 Substituted aminothiazoles as inhibitors of nucleases MASARYKOVA UNIVERZITA (CZ) 2023-02-21 US disclosed
US-20220002282-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2022-01-06 US disclosed
EP-3556755-B1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES UNIV MASARYKOVA (CZ) 2021-11-17 EP disclosed
US-20210088905-A1 ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, RESIST FILM, PATTERN FORMING METHOD, AND METHOD FOR MANUFACTURING ELECTRONIC DEVICE FUJIFILM CORPORATION (JP) 2021-03-25 US disclosed
US-4143127-A CONTAINING ADAMAMTANE RING COLGATE PALMOLIVE COMPANY (US) 1979-03-06 US disclosed
US-4123516-A Quaternary compounds having anti-microbial activity COLGATE-PALMOLIVE COMPANY (US) 1978-10-31 US disclosed
US-4123515-A Quaternary compounds having anti-microbial activity COLGATE-PALMOLIVE COMPANY (US) 1978-10-31 US disclosed
US-4123514-A Quaternary compounds having anti-microbial activity COLGATE-PALMOLIVE COMPANY (US) 1978-10-31 US disclosed
US-4123513-A Quaternary compounds having anti-microbial activity COLGATE-PALMOLIVE COMPANY (US) 1978-10-31 US disclosed
US-4036975-A FUNGICIDES, BACTERICIDES AND ANTIPROTOZOA AGENTS XYNTEX (U.S.A) INC. (US) 1977-07-19 US disclosed
US-3992431-A ALSO ANTICARIES AND ANTICALCULUS ACTIVITY COLGATE-PALMOLIVE COMPANY (US) 1976-11-16 US disclosed
US-3961074-A ANTICARIES AGENTS COLGATE-PALMOLIVE COMPANY (US) 1976-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11584742-B2 Substituted aminothiazoles as inhibitors of nucleases RNASEH1, DNASE1, FEN1 ALDH1A1 2267/4885TSHR 1512/4885GLA 1424/4885
US-20090123544-A1 STIMULUS-RESPONSIVE BIODEGRADABLE POLYMERS AND METHODS OF PREPARATION PAM, ATF4, MYD88 ALDH1A1 4408/4885TSHR 756/4885GLA 1217/4885
US-20220002282-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES RNASEH1, DNASE1, FEN1 ALDH1A1 2267/4885TSHR 1512/4885GLA 1424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.