Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 14/20 | 0.42 |
| ▸ | PPARA | Q07869 | 12/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9016553 | 0.84 | LDHA (0.40) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL29957366 | 0.84 | MTNR1A (0.45) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL1877273 | 0.82 | PPARG (0.51) | PPARGPPARA | |
| SCHEMBL9578330 | 0.82 | PPARG (0.45) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL5556068 | 0.82 | CYP2C19 (0.42) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL27650314 | 0.79 | CYP1A2 (0.40) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL4582830 | 0.79 | GAA (0.43) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL27363641 | 0.78 | TDP1 (0.49) | MTNR1AMTNR1BTSHR | |
| SCHEMBL1933913 | 0.78 | CYP1A2 (0.53) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL11322441 | 0.78 | CYP1A2 (0.53) | CYP1A2GAACYP2C9PKMCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630888-B1 | IMIDAZOLINE DERIVATIVE, PRODUCTION THEREOF, AND BLOOD PRESSURE RETENTIVE | MAEDA HIROSHI (JP) | 2001-04-04 | — | — | EP | claimed |
| EP-0630888-A1 | IMIDAZOLINE DERIVATIVE, PRODUCTION THEREOF, AND BLOOD PRESSURE RETENTIVE | Maeda, Hiroshi (JP) | 1994-12-28 | — | — | EP | claimed |
| US-11760773-B2 | Small molecule drug conjugates of gemcitabine monophosphate | MAVERIX ONCOLOGY, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| US-20210380626-A1 | NOVEL SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE DERIVATIVES | MAVERIX ONCOLOGY, INC. | 2021-12-09 | — | — | US | disclosed |
| US-20210040136-A1 | SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE MONOPHOSPHATE | MAVERIX ONCOLOGY, INC. | 2021-02-11 | — | — | US | disclosed |
| CN-112135634-A | Small molecule drug conjugate of gemcitabine monophosphate | 马福瑞克斯肿瘤学股份有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-112135635-A | Novel small molecule drug conjugate of gemcitabine derivative | 马福瑞克斯肿瘤学股份有限公司 | 2020-12-25 | — | — | CN | disclosed |
| EP-3746134-A1 | SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE MONOPHOSPHATE | MAVERIX ONCOLOGY, INC. (US) | 2020-12-09 | — | — | EP | disclosed |
| EP-3746133-A1 | NOVEL SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE DERIVATIVES | MAVERIX ONCOLOGY, INC. (US) | 2020-12-09 | — | — | EP | disclosed |
| WO-2019152955-A9 | SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE MONOPHOSPHATE | EVERETT STEVEN ALBERT (US) | 2020-08-13 | — | — | WO | disclosed |
| WO-2019152955-A1 | SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE MONOPHOSPHATE | EVERETT STEVEN ALBERT (US) | 2019-08-08 | — | — | WO | disclosed |
| US-5279927-A | Mixture of solvent, anionic surfactant, acid and buffer | EASTMAN KODAK COMPANY (US) | 1994-01-18 | — | — | US | disclosed |
| US-5275907-A | Diazo resin, acetal polymer and copolyester with unsaturated diacid and oxyalkylene ether of alkylidene diphenol | EASTMAN KODAK COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| US-5219699-A | Diazo resin, binder of a vinyl alcohol polymer acetalized with three different aldehydes | EASTMAN KODAK COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| WO-1993003068-A1 | ACID-SUBSTITUTED TERNARY ACETAL POLYMERS AND USE THEREOF IN PHOTOSENSITIVE COMPOSITIONS AND LITHOGRAPHIC PRINTING PLATES | EASTMAN KODAK COMPANY (US) | 1993-02-18 | — | — | WO | disclosed |
| US-5169898-A | Acid-substituted ternary acetal polymers useful in photosensitive compositions and lithographic printing plates | EASTMAN KODAK COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-4291060-A | Compounds derived from formylphenoxyacetic acid as antiviral agents in animals | PFIZER INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4291060-A | Compounds derived from formylphenoxyacetic acid as antiviral agents in animals | PFIZER INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4291060-A | Compounds derived from formylphenoxyacetic acid as antiviral agents in animals | PFIZER INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4226765-A | Novel rifamycin compounds of high antibiotic activity | ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO S.P.A. (IT) | 1980-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210380626-A1 | NOVEL SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE DERIVATIVES | ZYX, KRAS, SLC7A5 | CYP1A2 4659/4885GAA 591/4885CYP2C9 4255/4885 |
| US-11760773-B2 | Small molecule drug conjugates of gemcitabine monophosphate | ZYX, SLC7A5, GMPS | CYP1A2 4572/4885GAA 522/4885CYP2C9 3696/4885 |
| US-20210040136-A1 | SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE MONOPHOSPHATE | ZYX, SLC7A5, GMPS | CYP1A2 4551/4885GAA 509/4885CYP2C9 3666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.