Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ITGB2 | P05107 | 6/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.50 |
| ▸ | ITGAL | P20701 | 6/20 | 0.50 |
| ▸ | RHEB | Q15382 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3543373 | 0.91 | ATM (0.43) | ATMKDM4EL3MBTL1ITGB2ICAM1 | |
| SCHEMBL3541807 | 0.86 | ATM (0.40) | ATMKDM4EL3MBTL1ITGB2ICAM1 | |
| SCHEMBL3547722 | 0.83 | ATM (0.42) | ATMKDM4EL3MBTL1ITGB2ICAM1 | |
| SCHEMBL3538161 | 0.83 | PDE7A (0.47) | ATMKDM4EL3MBTL1RHEBPLA2G1B | |
| SCHEMBL3541411 | 0.81 | MEN1 (0.47) | ATMKDM4EL3MBTL1RHEBNPSR1 | |
| SCHEMBL3546438 | 0.80 | HTR1A (0.43) | ATMKDM4EL3MBTL1NPSR1PDE7A | |
| SCHEMBL28941715 | 0.79 | ATM (0.50) | ATMKDM4EL3MBTL1ITGB2ICAM1 | |
| SCHEMBL3165346 | 0.79 | ITGB2 (0.72) | ATMKDM4EL3MBTL1ITGB2ICAM1 | |
| SCHEMBL3546700 | 0.79 | PDE7A (0.60) | ITGB2ICAM1ITGALRHEBPDE7A | |
| Hydrochloric Acid SCHEMBL7604738 | 0.78 | ITGB2 (0.77) | ATMKDM4EL3MBTL1ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732463-B2 | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2010-06-08 | — | — | US | disclosed |
| US-20060100242-A1 | such as 4-[2-(4-Chloro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-piperidine, used as antidepressants and anxiolytic agents; treatment of panic and obsessive compulsive disorders | H.LUNDBECK A/S (DK) | 2006-05-11 | — | — | US | disclosed |
| EP-1626720-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004087156-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100242-A1 | such as 4-[2-(4-Chloro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-piperidine, used as antidepressants and anxiolytic agents; treatment of panic and obsessive compulsive disorders | HTR4, HTR5A, TPH1 | ATM 3209/4885KDM4E 1091/4885L3MBTL1 4197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.