Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827611 | 0.84 | HDAC1 (0.60) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13753861 | 0.83 | DRD2 (0.84) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL10674230 | 0.81 | KDM4E (0.70) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL74104 | 0.80 | DRD2 (1.00) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL5161463 | 0.80 | IDO1 (0.55) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL6632042 | 0.80 | KDM4E (0.71) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL20267113 | 0.80 | KDM4E (0.72) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL9397179 | 0.80 | DRD2 (0.74) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL27550290 | 0.80 | AKR1C3 (0.86) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL7374142 | 0.79 | HDAC1 (0.72) | DRD2DRD3HTR2CKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732436-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-06-08 | — | — | US | disclosed |
| US-7601710-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2009-10-13 | — | — | US | disclosed |
| US-7601710-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2009-10-13 | — | — | US | disclosed |
| US-7385055-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2008-06-10 | — | — | US | disclosed |
| US-7335769-B2 | Preparation of hymenialdsine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2008-02-26 | — | — | US | disclosed |
| US-7193079-B1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-03-20 | — | — | US | disclosed |
| US-7193079-B1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-03-20 | — | — | US | disclosed |
| US-7193079-B1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-03-20 | — | — | US | disclosed |
| US-20070049575-A1 | PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2007-03-01 | — | — | US | disclosed |
| US-20070049575-A1 | PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2007-03-01 | — | — | US | disclosed |
| US-20060293305-A1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2006-12-28 | — | — | US | disclosed |
| US-20060287296-A1 | Preparation of hymenialdsine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2006-12-21 | — | — | US | disclosed |
| US-20060276451-A1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2006-12-07 | — | — | US | disclosed |
| WO-2004103958-A2 | PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF | MICHIGAN STATE UNIVERSITY (US) | 2004-12-02 | — | — | WO | disclosed |
| US-20040235820-A1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287296-A1 | Preparation of hymenialdsine derivatives and use thereof | IDO2, CHEK2, NFKBIA | DRD2 1635/4885DRD3 3570/4885HTR2C 419/4885 |
| US-20040235820-A1 | Preparation of hymenialdisine derivatives and use thereof | NFKBIA, IKBKG, GSK3B | DRD2 2244/4885DRD3 3693/4885HTR2C 411/4885 |
| US-20070049575-A1 | PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF | IDO2, CHEK2, NFKBIA | DRD2 2069/4885DRD3 3921/4885HTR2C 415/4885 |
| US-20060276451-A1 | Preparation of hymenialdisine derivatives and use thereof | IDO2, CHEK2, NFKBIA | DRD2 2069/4885DRD3 3921/4885HTR2C 415/4885 |
| US-20060293305-A1 | Preparation of hymenialdisine derivatives and use thereof | IDO2, CHEK2, NFKBIA | DRD2 2069/4885DRD3 3921/4885HTR2C 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.