Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547635 | 0.74 | HPGD (0.53) | HPGDLMNAALDH1A1KDM4EHTT | |
| SCHEMBL3555926 | 0.74 | HPGD (0.53) | HPGDLMNAALDH1A1KDM4EHTT | |
| SCHEMBL3547004 | 0.74 | HPGD (0.53) | HPGDLMNAALDH1A1KDM4EHTT | |
| SCHEMBL4573985 | 0.74 | ASAH1 (0.42) | HPGDNAAAALDH1A1KDM4ENAMPT | |
| SCHEMBL13817440 | 0.74 | HPGD (0.43) | HPGDNAAALMNAALDH1A1NAMPT | |
| SCHEMBL13817441 | 0.73 | HPGD (0.42) | HPGDNAAALMNAALDH1A1NAMPT | |
| SCHEMBL8551142 | 0.69 | HPGD (0.47) | HPGDNAAAALDH1A1NAMPTASAH1 | |
| SCHEMBL8554153 | 0.68 | HPGD (0.46) | HPGDNAAALMNAALDH1A1NAMPT | |
| SCHEMBL4573986 | 0.68 | NAAA (0.43) | HPGDNAAALMNAALDH1A1NAMPT | |
| SCHEMBL8549785 | 0.67 | HPGD (0.46) | HPGDNAAAALDH1A1NAMPTASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143446-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-06-04 | — | — | US | claimed |
| EP-1692121-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF | University of Tennessee Research Foundation (US) | 2006-08-23 | — | — | EP | claimed |
| US-20060040998-A1 | Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2006-02-23 | — | — | US | claimed |
| WO-2005049591-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2005-06-02 | — | — | WO | claimed |
| US-7662842-B2 | Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents | Ohio State Univesity Research Foundation (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090143446-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-06-04 | — | — | US | disclosed |
| US-20080255213-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2008-10-16 | — | — | US | disclosed |
| US-7307093-B2 | Cancer, selectivity to prostate cancer cell lines, ovarian cancer cells | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2007-12-11 | — | — | US | disclosed |
| US-20070155807-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2007-07-05 | — | — | US | disclosed |
| CN-1902184-A | Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof | UNIV TENNESSEE RES FOUNDATION (US) | 2007-01-24 | — | — | CN | disclosed |
| US-20060040998-A1 | Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2006-02-23 | — | — | US | disclosed |
| US-20060014740-A1 | Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof | US GOVERNMENT - SECRETARY FOR THE ARMY | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143446-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF | NAT1, AADAC, PPARG | HPGD 371/4885NAAA 151/4885LMNA 4427/4885 |
| US-20060014740-A1 | Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof | MKI67, MCL1, API5 | HPGD 242/4885NAAA 1410/4885LMNA 2940/4885 |
| US-20060040998-A1 | Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof | NAT1, AADAC, PPARG | HPGD 371/4885NAAA 151/4885LMNA 4427/4885 |
| US-20080255213-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS | SRM, SAT1, SMS | HPGD 1254/4885NAAA 141/4885LMNA 4179/4885 |
| US-20070155807-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS | SRM, SAT1, SMS | HPGD 969/4885NAAA 203/4885LMNA 4327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.