Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | EBP | Q15125 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560527 | 1.00 | SIGMAR1 (0.49) | SIGMAR1EBPCA1CA2CA9 | |
| SCHEMBL5181144 | 0.87 | CA12 (0.53) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL3546960 | 0.87 | CA12 (0.53) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL8828288 | 0.81 | SIGMAR1 (0.54) | SIGMAR1EBPTMEM97HTR1ASLC6A4 | |
| SCHEMBL27334030 | 0.77 | SIGMAR1 (0.56) | SIGMAR1EBPTMEM97CHRM3HTR1A | |
| SCHEMBL3553421 | 0.77 | DPP4 (0.63) | SIGMAR1EBPTMEM97HTR1ASLC6A4 | |
| SCHEMBL9739025 | 0.76 | HTR1A (0.56) | SIGMAR1EBPTMEM97HTR1ASLC6A4 | |
| SCHEMBL5192115 | 0.75 | DRD4 (0.48) | SIGMAR1EBPTMEM97CHRM3ALDH1A1 | |
| SCHEMBL10338903 | 0.75 | KMT2A (0.67) | ALDH1A1KDM4E | |
| SCHEMBL17304798 | 0.74 | EBP (0.54) | SIGMAR1EBPTMEM97ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087485-A1 | 4-AMINOPIPERIDINE DERIVATIVES | BOEHRINGER MARKUS | 2010-04-08 | — | — | US | disclosed |
| US-7683079-B2 | 4-aminopiperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-23 | — | — | US | disclosed |
| EP-1831165-A1 | 4-AMINOPIPERIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066747-A1 | 4-AMINOPIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |
| US-20060135561-A1 | 4-Aminopiperidine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087485-A1 | 4-AMINOPIPERIDINE DERIVATIVES | DPP4, GPR119, IAPP | SIGMAR1 119/4885EBP 229/4885CA1 4027/4885 |
| US-20060135561-A1 | 4-Aminopiperidine derivatives | DPP4, GPR119, IAPP | SIGMAR1 119/4885EBP 229/4885CA1 4027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.