Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL129085 | 0.89 | RXRA (0.45) | RXRARXRBRXRGIDO1TSHR | |
| SCHEMBL2773850 | 0.89 | RXRA (0.45) | RXRARXRBRXRGIDO1TSHR | |
| SCHEMBL3558741 | 0.80 | RXRA (0.39) | RXRARXRBRXRGIDO1TSHR | |
| SCHEMBL15651082 | 0.80 | ACHE (0.39) | — | |
| SCHEMBL5473657 | 0.80 | TSHR (0.46) | IDO1TSHRMAPK1NR2E1ALDH1A1 | |
| SCHEMBL265486 | 0.75 | IDO1 (0.52) | RXRARXRBRXRGIDO1PRKCA | |
| SCHEMBL12398665 | 0.75 | IDO1 (0.41) | IDO1TSHRMAPK1MAOBNR2E1 | |
| SCHEMBL14785302 | 0.75 | RXRA (0.33) | RXRARXRBRXRGTSHRMAPK1 | |
| SCHEMBL14169221 | 0.74 | IDO1 (0.44) | IDO1TSHRMAOBTAAR1 | |
| SCHEMBL864911 | 0.74 | IDO1 (0.47) | IDO1TSHRMAPK1MAOBNR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737811-B1 | CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2016-08-10 | — | — | EP | disclosed |
| US-8193365-B2 | CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20100249024-A1 | CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-09-30 | — | — | US | disclosed |
| US-7737295-B2 | CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-06-15 | — | — | US | disclosed |
| US-20070225365-A1 | Cetp Inhibitors | MERCK & CO., INC. (US) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225365-A1 | Cetp Inhibitors | CETP, APOB, NPC1 | RXRA 2001/4885RXRB 2413/4885RXRG 1901/4885 |
| US-20100249024-A1 | CETP INHIBITORS | CETP, APOB, NPC1 | RXRA 2001/4885RXRB 2413/4885RXRG 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.