Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.57 |
| ▸ | METAP1 | P53582 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | S100A4 | P26447 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18533284 | 0.85 | MAOB (0.47) | MAOBMETAP1NOTUMCYP19A1S100A4 | |
| SCHEMBL10977113 | 0.79 | METAP1 (0.53) | MAOBMETAP1CYP19A1MAPTRAB9A | |
| SCHEMBL3557966 | 0.79 | APP (0.57) | METAP1CYP19A1S100A4MAPTRAB9A | |
| SCHEMBL22049536 | 0.79 | MAOB (0.57) | MAOBNOTUMCYP19A1S100A4MAPT | |
| SCHEMBL6966149 | 0.78 | MAOB (0.55) | MAOBNOTUMCYP19A1S100A4MAPT | |
| SCHEMBL69423 | 0.78 | MAOB (0.55) | MAOBNOTUMCYP19A1S100A4MAPT | |
| SCHEMBL8797952 | 0.77 | MAPT (0.68) | MAOBMAPTRAB9AALDH1A1MAPK14 | |
| SCHEMBL28827715 | 0.76 | ALDH1A1 (0.65) | MAOBMETAP1CYP19A1MAPTRAB9A | |
| SCHEMBL29817556 | 0.76 | ALDH1A1 (0.65) | MAOBMETAP1CYP19A1MAPTRAB9A | |
| SCHEMBL3553528 | 0.74 | PKM (0.59) | MAOBMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642283-B2 | modulating the activity of the mitochrondrial permeability transition pore complex comprising exposing the complex to a compound such as 6-bromo-3-methylene-chroman-4-one | HOFFMANN-LA ROCHE INC. (US) | 2010-01-05 | — | — | US | disclosed |
| EP-1468995-B1 | MPTP affinity labels | HOFFMANN LA ROCHE (CH) | 2008-05-14 | — | — | EP | disclosed |
| US-20060252822-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | CESURA ANDREA | 2006-11-09 | — | — | US | disclosed |
| US-7101917-B2 | Mitochrondrial permeability transition pore affinity labels and modulators | HOFFMANN-LA ROCHE INC. (US) | 2006-09-05 | — | — | US | disclosed |
| US-20040220257-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | HOFFMANN-LA ROCHE INC. | 2004-11-04 | — | — | US | disclosed |
| EP-1468995-A1 | MPTP affinity labels | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220257-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | MCU, ATP5PB, MFN2 | MAOB 1048/4885METAP1 1423/4885NOTUM 3479/4885 |
| US-20060252822-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | MCU, ATP5PB, MFN2 | MAOB 1048/4885METAP1 1423/4885NOTUM 3479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.