Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963034 | 0.84 | NISCH (0.36) | TLR9TLR8TLR7KDM4EALDH1A1 | |
| SCHEMBL3520926 | 0.78 | ADORA2A (0.33) | — | |
| SCHEMBL2955031 | 0.73 | STAT3 (0.52) | — | |
| SCHEMBL2963039 | 0.71 | STAT3 (0.50) | — | |
| SCHEMBL2955029 | 0.71 | IDO1 (0.36) | ALDH1A1 | |
| SCHEMBL29834821 | 0.71 | IDO1 (0.36) | ALDH1A1 | |
| SCHEMBL2962139 | 0.70 | IDO1 (0.35) | ALDH1A1 | |
| Methoxymethane SCHEMBL28698428 | 0.68 | STAT3 (0.38) | — | |
| Methoxymethane SCHEMBL27581743 | 0.68 | STAT3 (0.38) | — | |
| SCHEMBL3336067 | 0.67 | STAT3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718201-B1 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2016-09-14 | — | — | EP | disclosed |
| US-20150344509-A1 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2015-12-03 | — | — | US | disclosed |
| US-9096628-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140080797-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2014-03-20 | — | — | US | disclosed |
| US-8618089-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2013-12-31 | — | — | US | disclosed |
| US-20120264725-A1 | SUBSTITUTED PORPHYRINS | BATINIC-HABERLE INES (US) | 2012-10-18 | — | — | US | disclosed |
| US-8183364-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2012-05-22 | — | — | US | disclosed |
| US-20100305083-A1 | SUBSTITUTED PORPHYRINS | BATINIC-HABERLE INES | 2010-12-02 | — | — | US | disclosed |
| US-7807825-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2010-10-05 | — | — | US | disclosed |
| US-20080021007-A1 | Substituted Porphyrins | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344509-A1 | SUBSTITUTED PORPHYRINS | PPOX, FECH, MB | TLR9 2470/4885TLR8 3482/4885TLR7 3242/4885 |
| US-20120264725-A1 | SUBSTITUTED PORPHYRINS | PPOX, FECH, MB | TLR9 2470/4885TLR8 3482/4885TLR7 3242/4885 |
| US-20080021007-A1 | Substituted Porphyrins | SOD3, SOD1, PRDX3 | TLR9 3729/4885TLR8 4177/4885TLR7 3984/4885 |
| US-20140080797-A1 | SUBSTITUTED PORPHYRINS | PPOX, FECH, MB | TLR9 2470/4885TLR8 3482/4885TLR7 3242/4885 |
| US-20100305083-A1 | SUBSTITUTED PORPHYRINS | SOD3, SOD1, PRDX3 | TLR9 3750/4885TLR8 4234/4885TLR7 4006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.