Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrazine SCHEMBL5719663 | 0.96 | ACHE (0.34) | ACHECHRM2CHRM4CHRM5CYP2D6 | |
| SCHEMBL7523913 | 0.80 | ACHE (0.38) | ACHECHRM2CHRM4CHRM5CYP2D6 | |
| SCHEMBL11924487 | 0.80 | CHRNB2 (0.52) | ACHECHRM2CHRM4CHRM5CYP2D6 | |
| SCHEMBL22898364 | 0.79 | ACHE (0.38) | ACHECHRNB2CHRNA4 | |
| Water SCHEMBL5719666 | 0.79 | ACHE (0.32) | ACHE | |
| SCHEMBL24735973 | 0.78 | ACHE (0.41) | ACHECHRNB2CHRNA4 | |
| SCHEMBL5031468 | 0.78 | CHRNB2 (0.50) | ACHECHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL28538773 | 0.78 | ACHE (0.36) | ACHECHRM2CHRM4CHRM5CYP2D6 | |
| SCHEMBL10113926 | 0.78 | ACHE (0.41) | ACHECHRM2CHRM4CHRM5CYP2D6 | |
| SCHEMBL6946858 | 0.78 | ACHE (0.46) | ACHECHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696707-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| CN-106414473-B | Polyene macrolide derivatives | 盐野义制药株式会社 | 2020-03-13 | — | — | CN | disclosed |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2019-05-09 | — | — | US | disclosed |
| US-10246478-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2019-04-02 | — | — | US | disclosed |
| CN-108778289-A | TRITERPENE SAPONIN ANALOGUES | 佐剂技术公司 | 2018-11-09 | — | — | CN | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
| EP-3156410-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-04-19 | — | — | EP | disclosed |
| CN-106573951-A | Micro saponin analogue, synthesis and use thereof | 索隆-基特林癌症研究协会 | 2017-04-19 | — | — | CN | disclosed |
| CN-106414473-A | Polyene macrolide derivative | 盐野义制药株式会社 | 2017-02-15 | — | — | CN | disclosed |
| WO-2016120808-A1 | HETEROARYLAMINOISOQUINOLINES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | MINORYX THERAPEUTICS S.L. (ES) | 2016-08-04 | — | — | WO | disclosed |
| US-6545108-B1 | Ti, Zr, Hf, Cr, Mo, W, V, Nb, or Ta complex of a monodentate dianionic ligand in which a nitrogen atom is substituted by a 1-pyrrolyl and the remaining donor atoms are N, P, As, O, S, or Se | EASTMAN CHEMICAL COMPANY | 2003-04-08 | — | — | US | disclosed |
| EP-1290048-A2 | COPOLYMERIZATION OF NORBORNENE AND FUNCTIONAL NORBORNENE MONOMERS | EASTMAN CHEMICAL COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1278784-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2003-01-29 | — | — | EP | disclosed |
| US-20030013894-A1 | Process for the preparation of ligands for olefin polymerization catalysts | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-01-16 | — | — | US | disclosed |
| WO-2002036585-A2 | PROCESS FOR THE PREPARATION OF LIGANDS FOR OLEFIN POLYMERIZATION CATALYSTS | EASTMAN CHEMICAL COMPANY (US) | 2002-05-10 | — | — | WO | disclosed |
| CN-1347423-A | Catalyst contg. N-pyrrolyl substd. nitrogen donors | EASTMAN CHEM CO (US) | 2002-05-01 | — | — | CN | disclosed |
| EP-1192189-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001096406-A2 | COPOLYMERIZATION OF NORBORNENE AND FUNCTIONAL NORBORNENE MONOMERS | EASTMAN CHEMICAL COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001083571-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000050470-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2000-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013894-A1 | Process for the preparation of ligands for olefin polymerization catalysts | OCIAD1, OXER1, SULT1E1 | ACHE 2122/4885CHRM2 962/4885CHRM4 430/4885 |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | ACHE 4396/4885CHRM2 4812/4885CHRM4 4338/4885 |
| US-10246478-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | ACHE 4396/4885CHRM2 4812/4885CHRM4 4338/4885 |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | ACHE 4396/4885CHRM2 4812/4885CHRM4 4338/4885 |
| US-10696707-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | ACHE 4396/4885CHRM2 4812/4885CHRM4 4338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.