Sugi Predict

Sugi Predict / Compounds / Hydrazine

Hydrazine

Hydrazine

SCHEMBL3559520

CC(C)c1nc(-n2ccnc2)ns1.NN

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 7/20 0.38
▸ MAPK1 P28482 3/20 0.38
▸ CYP3A4 P08684 2/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ CYP2D6 P10635 1/20 0.38
▸ CYP2C9 P11712 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ HSD17B10 Q99714 2/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ LMNA P02545 4/20 0.37
▸ USP2 O75604 2/20 0.37
▸ NPSR1 Q6W5P4 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ NOS2 P35228 6/20 0.35
▸ MAPT P10636 2/20 0.34
▸ CYP19A1 P11511 1/20 0.34
▸ CYP11B1 P15538 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrazine SCHEMBL3567840 0.85 TSHR (0.37) TSHRMAPK1CYP3A4CYP1A2CYP2D6
SCHEMBL13037127 0.75 LMNA (0.42) TSHRMAPK1CYP3A4CYP1A2CYP2D6
SCHEMBL3558775 0.73 NOTUM (0.44) TSHRMAPK1CYP3A4CYP1A2CYP2D6
SCHEMBL3557965 0.69 CYP3A4 (0.46) TSHRMAPK1CYP3A4CYP1A2CYP2D6
SCHEMBL3561799 0.69 KDM4E (0.39) TSHRMAPK1CYP1A2CYP2D6CYP2C9
SCHEMBL16022250 0.68 ADORA2A (0.40) MAPK1L3MBTL1NPC1LMNANPSR1
SCHEMBL13037158 0.68 NOS2 (0.54) TSHRMAPK1CYP3A4CYP1A2CYP2D6
SCHEMBL9025866 0.67 LMNA (0.67) TSHRMAPK1CYP3A4CYP1A2CYP2D6
SCHEMBL13037134 0.66 NOS2 (0.58) TSHRMAPK1CYP3A4CYP1A2CYP2D6
SCHEMBL8081073 0.65 TSHR (0.43) TSHRMAPK1CYP3A4CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7825256-B2 Inducible nitric oxide synthase dimerization inhibitors KALYPSYS, INC. (US) 2010-11-02 — — US disclosed
US-20100094021-A1 NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES KALYPSYS, INC. (US) 2010-04-15 — — US disclosed
US-20070123572-A1 NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES KALYPSYS, INC. (US) 2007-05-31 — — US disclosed
US-20060116515-A1 Inducible nitric oxide synthase dimerization inhibitors KALYPSYS, INC. 2006-06-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100094021-A1 NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES DCLK2, TH, DCLK3 TSHR 843/4885MAPK1 1339/4885CYP3A4 668/4885
US-20070123572-A1 NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES DCLK2, TH, DCLK3 TSHR 843/4885MAPK1 1339/4885CYP3A4 668/4885
US-20060116515-A1 Inducible nitric oxide synthase dimerization inhibitors NOS3, NOS2, NOS1 TSHR 788/4885MAPK1 3125/4885CYP3A4 80/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.