Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 15/20 | 0.39 |
| ▸ | NOS1 | P29475 | 11/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569290 | 0.84 | NOS2 (0.57) | NOS2NOS1POLBNPC1TSHR | |
| SCHEMBL3564769 | 0.74 | NOS2 (0.37) | NOS2NOS1POLBPDE5A | |
| SCHEMBL3559005 | 0.73 | NOS2 (0.38) | NOS2NOS1NPC1TSHRHSD17B10 | |
| SCHEMBL3620097 | 0.72 | NOS2 (0.41) | NOS2NOS1 | |
| SCHEMBL3562878 | 0.72 | NOS2 (0.72) | NOS2NOS1 | |
| SCHEMBL3615118 | 0.72 | TSHR (0.38) | NOS2NOS1POLBTSHRHSD17B10 | |
| SCHEMBL3566903 | 0.71 | NOS2 (0.50) | NOS2NOS1 | |
| SCHEMBL3567894 | 0.70 | NOS2 (0.56) | NOS2NOS1 | |
| SCHEMBL3568583 | 0.70 | NOS2 (0.35) | NOS2NOS1NPC1TSHRHSD17B10 | |
| SCHEMBL3556926 | 0.69 | NOS2 (0.46) | NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825256-B2 | Inducible nitric oxide synthase dimerization inhibitors | KALYPSYS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |