Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | HCN1 | O60741 | 4/20 | 0.31 |
| ▸ | HCN4 | Q9Y3Q4 | 3/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733522 | 0.87 | SLC6A5 (0.32) | ALOX5 | |
| SCHEMBL3576920 | 0.83 | CRHBP (0.34) | TP53SIGMAR1CHRM2KMT2AHTT | |
| SCHEMBL14279647 | 0.76 | GAA (0.36) | TP53SIGMAR1GAARAD52KMT2A | |
| SCHEMBL11131038 | 0.76 | SIRT2 (0.31) | — | |
| Ethylene SCHEMBL11120166 | 0.74 | — | — | |
| SCHEMBL3578626 | 0.73 | KMT2A (0.34) | TP53KMT2A | |
| SCHEMBL9356126 | 0.73 | HSD17B10 (0.36) | GAAALOX5 | |
| SCHEMBL735929 | 0.71 | KMT2A (0.43) | TP53SIGMAR1HCN1HCN4GAA | |
| Ethylene SCHEMBL11118708 | 0.70 | MEN1 (0.31) | KMT2A | |
| SCHEMBL9356226 | 0.70 | HSD17B10 (0.34) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121689-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2013-07-31 | — | — | EP | disclosed |
| US-8404740-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-20100048554-A1 | Spirocyclic Cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2010-02-25 | — | — | US | disclosed |
| EP-2121689-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008101659-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048554-A1 | Spirocyclic Cyclohexane Compounds | OPRL1, OPRD1, OPRK1 | TP53 4717/4885SIGMAR1 8/4885HCN1 943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.