Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3564987 | 1.00 | APP (0.46) | APPALDH1A1RETAPAF1PRMT1 | |
| SCHEMBL3563633 | 0.82 | APP (0.50) | APPALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL3563637 | 0.82 | APP (0.50) | APPALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL25019712 | 0.74 | MEN1 (0.52) | APPALDH1A1APAF1PRMT1HPGD | |
| SCHEMBL15080557 | 0.74 | ALDH1A1 (0.53) | APPALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL3565158 | 0.71 | CASP3 (0.44) | APPALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL3565159 | 0.71 | CASP3 (0.44) | APPALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL4865457 | 0.67 | ALDH1A1 (0.42) | ALDH1A1HPGDGAASMN1; SMN2KDM4E | |
| SCHEMBL4865450 | 0.67 | ALDH1A1 (0.42) | ALDH1A1HPGDGAASMN1; SMN2KDM4E | |
| SCHEMBL3567605 | 0.67 | ALDH1A1 (0.61) | ALDH1A1HPGDGAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | claimed |