Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.83 |
| ▸ | HPGD | P15428 | 4/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.83 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509122 | 0.91 | KDM4E (1.00) | ALDH1A1HPGDKDM4EMEN1POLB | |
| SCHEMBL5446777 | 0.90 | ALDH1A1 (0.68) | ALDH1A1HPGDKDM4EMEN1POLB | |
| Hydrochloric Acid SCHEMBL30353212 | 0.90 | ALDH1A1 (0.97) | ALDH1A1HPGDKDM4EMEN1POLB | |
| Ammonia Solution, Strong SCHEMBL28187483 | 0.90 | ALDH1A1 (0.97) | ALDH1A1HPGDKDM4EMEN1POLB | |
| Fluoride SCHEMBL5823412 | 0.88 | ALDH1A1 (0.94) | ALDH1A1HPGDKDM4EMEN1POLB | |
| SCHEMBL14410811 | 0.87 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4EMEN1POLB | |
| SCHEMBL9936554 | 0.87 | NR4A2 (0.70) | ALDH1A1HPGDKDM4EMEN1POLB | |
| SCHEMBL5823415 | 0.86 | KDM4E (0.90) | ALDH1A1HPGDKDM4EMEN1POLB | |
| SCHEMBL6029339 | 0.84 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4EMEN1POLB | |
| SCHEMBL27436908 | 0.84 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239882-B1 | FORMULATIONS OF ADENOSINE A1 AGONISTS AND 5HT3 AGONISTS | GLAXO GROUP LTD (GB) | 2004-09-29 | — | — | EP | claimed |
| US-20030018008-A1 | Formulations of adenosine a1 agonists | BOUNTRA CHARANJIT (GB) | 2003-01-23 | — | — | US | claimed |
| EP-1239882-A2 | FORMULATIONS OF ADENOSINE A1 AGONISTS | GLAXO GROUP LIMITED (GB) | 2002-09-18 | — | — | EP | claimed |
| WO-2001045685-A2 | FORMULATIONS OF ADENOSINE A1 AGONISTS | GLAXO GROUP LIMITED (GB) | 2001-06-28 | — | — | WO | claimed |
| EP-0491664-B1 | Indole derivatives as serotonin antagonists | CIBA GEIGY AG (CH) | 1998-03-04 | — | — | EP | claimed |
| JP-4308590-A | — | — | None | — | — | JP | disclosed |
| WO-2018009539-A1 | INHIBITORS OF HEXOKINASE AND METHODS OF USE THEREOF | VTV THERAPEUTICS LLC (US) | 2018-01-11 | — | — | WO | disclosed |
| US-20170166561-A1 | QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | ALPHARMAGEN LLC (US) | 2017-06-15 | — | — | US | disclosed |
| US-9434724-B2 | Quinuclidines for modulating alpha 7 activity | ALPHARMAGEN, LLC (US) | 2016-09-06 | — | — | US | disclosed |
| EP-2595989-B1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2016-07-13 | — | — | EP | disclosed |
| US-20160009706-A1 | QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY | ALPHARMAGEN, LLC | 2016-01-14 | — | — | US | disclosed |
| WO-2016007630-A1 | QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7 -NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | ALPHARMAGEN, LLC (US) | 2016-01-14 | — | — | WO | disclosed |
| EP-0491664-B1 | Indole derivatives as serotonin antagonists | CIBA GEIGY AG (CH) | 1998-03-04 | — | — | EP | disclosed |
| WO-1997010823-A1 | 5-HT3 RECEPTOR ANTAGONISTS FOR DYSKINESIA | GLAXO GROUP LIMITED (GB) | 1997-03-27 | — | — | WO | disclosed |
| US-5543426-A | Use of certain 3,7-disubstituted indole compounds for treating depression or cognitive disorders | SANDOZ LTD. (CH) | 1996-08-06 | — | — | US | disclosed |
| US-5272154-A | 3,7 substituted indole and indazole compounds and pharmaceutical compositions containing them | SANDOZ LTD. (CH) | 1993-12-21 | — | — | US | disclosed |
| JP-H04308590-A | SERETONINE ANTAGONIST | SANDOZ AG | 1992-10-30 | — | — | JP | disclosed |
| EP-0491664-A1 | Serotonin antagonists | SANDOZ LTD. (CH) | 1992-06-24 | — | — | EP | disclosed |
| US-4966913-A | FOR FALL ARMYWORM AND EUROPEAN CORN BORER | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1990-10-30 | — | — | US | disclosed |
| US-4942247-A | SULFIDE DERIVATIVES OF NITRILES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1990-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018008-A1 | Formulations of adenosine a1 agonists | ADORA1, ADORA3, ADORA2A | ALDH1A1 346/4885HPGD 1618/4885KDM4E 3640/4885 |
| US-20160009706-A1 | QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY | CHRNA7, CHRNA2, CHRNA5 | ALDH1A1 1525/4885HPGD 1919/4885KDM4E 3461/4885 |
| US-20170166561-A1 | QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | CHRNA7, CHRNA2, CHRNA6 | ALDH1A1 1497/4885HPGD 1391/4885KDM4E 3528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.