Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.37 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL119824 | 0.89 | LMNA (0.67) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Succinic Acid SCHEMBL3191898 | 0.87 | MEN1 (0.57) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL16684846 | 0.87 | MEN1 (0.57) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL7043034 | 0.87 | MEN1 (0.57) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL316506 | 0.86 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1686208 | 0.86 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL2222247 | 0.86 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL10630113 | 0.86 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1686210 | 0.86 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL119826 | 0.86 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250354930-A1 | IONIC LIQUID ENCAPSULATION OF NIR DYES FOR THE IMPROVEMENT OF BLOODSTAIN DETECTION | UNIV MISSISSIPPI (US) | 2025-11-20 | — | — | US | claimed |
| US-20220356272-A1 | PROCESSES FOR EXTRACTING AND PURIFYING CHITIN BY USING GREEN SOLVENTS | POLITECNICO DI MILANO (IT) | 2022-11-10 | — | — | US | claimed |
| EP-4034572-A1 | PROCESS FOR EXTRACTING AND PURIFYING CHITIN BY USING GREEN SOLVENTS | Politecnico di Milano (IT) | 2022-08-03 | — | — | EP | claimed |
| WO-2021059119-A1 | PROCESS FOR EXTRACTING AND PURIFYING CHITIN BY USING GREEN SOLVENTS | POLITECNICO DI MILANO (IT) | 2021-04-01 | — | — | WO | claimed |
| EP-2638123-B1 | WORKING MEDIUM FOR ABSORPTION HEAT PUMPS | EVONIK DEGUSSA GMBH (DE) | 2016-08-31 | — | — | EP | claimed |
| EP-2638123-A1 | WORKING MEDIUM FOR ABSORPTION HEAT PUMPS | Evonik Degussa GmbH (DE) | 2013-09-18 | — | — | EP | claimed |
| US-20130219949-A1 | WORKING MEDIUM FOR ABSORPTION HEAT PUMPS | EVONIK DEGUSSA GMBH (DE) | 2013-08-29 | — | — | US | claimed |
| US-8187489-B1 | Biodegradable ionic liquids for aircraft deicing | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-29 | — | — | US | claimed |
| WO-2012062656-A1 | WORKING MEDIUM FOR ABSORPTION HEAT PUMPS | EVONIK DEGUSSA GMBH (DE) | 2012-05-18 | — | — | WO | claimed |
| EP-2414476-A1 | IONIC COMPOUNDS IN LITHIUM BROMIDE/WATER ABSORPTION CYCLE SYSTEMS | E. I. du Pont de Nemours and Company (US) | 2012-02-08 | — | — | EP | claimed |
| US-20120011886-A1 | IONIC COMPOUNDS IN LITHIUM BROMIDE/WATER ABSORPTION CYCLE SYSTEMS | E. I. DU PONT DE NEMOURS AND COMPANY | 2012-01-19 | — | — | US | claimed |
| WO-2010117836-A1 | IONIC COMPOUNDS IN LITHIUM BROMIDE/WATER ABSORPTION CYCLE SYSTEMS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-10-14 | — | — | WO | claimed |
| US-20250354930-A1 | IONIC LIQUID ENCAPSULATION OF NIR DYES FOR THE IMPROVEMENT OF BLOODSTAIN DETECTION | UNIV MISSISSIPPI (US) | 2025-11-20 | — | — | US | disclosed |
| US-20250354930-A1 | IONIC LIQUID ENCAPSULATION OF NIR DYES FOR THE IMPROVEMENT OF BLOODSTAIN DETECTION | UNIV MISSISSIPPI (US) | 2025-11-20 | — | — | US | disclosed |
| US-12441959-B2 | Composition containing organic ammonium salt | MIYOSHI OIL & FAT CO., LTD. (JP) | 2025-10-14 | — | — | US | disclosed |
| US-20250090437-A1 | COSMETIC COMPOUNDING AGENT, COSMETIC AND PRODUCTION METHOD THEREOF | MIYOSHI YUSHI KK (JP) | 2025-03-20 | — | — | US | disclosed |
| US-20080039345-A1 | Shale inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, L.L.C. | 2008-02-14 | — | — | US | disclosed |
| US-7268100-B2 | Shale inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, LLC (US) | 2007-09-11 | — | — | US | disclosed |
| US-20060194700-A1 | Corrosion inhibitor systems for low, moderate and high temperature fluids and methods for making and using same | WEATHERFORD/LAMB | 2006-08-31 | — | — | US | disclosed |
| US-20060116296-A1 | Shale Inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, L.L.C. | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12441959-B2 | Composition containing organic ammonium salt | SLC6A15, SLC38A7, SLC6A19 | MEN1 4282/4885LMNA 4201/4885KMT2A 2282/4885 |
| US-20250090437-A1 | COSMETIC COMPOUNDING AGENT, COSMETIC AND PRODUCTION METHOD THEREOF | CUTA, HAT1, NACA | MEN1 643/4885LMNA 3747/4885KMT2A 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.