Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568304 | 0.95 | ALOX5 (0.40) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3565898 | 0.94 | LMNA (0.43) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3570708 | 0.91 | ALDH1A1 (0.45) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3560450 | 0.91 | CA12 (0.45) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2295378 | 0.90 | CA12 (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2924743 | 0.90 | CA12 (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3565901 | 0.89 | KDM4E (0.40) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3570710 | 0.87 | ALDH1A1 (0.42) | TSHRALDH1A1ALOX5KDM4EMAPK1 | |
| SCHEMBL3560451 | 0.86 | ALDH1A1 (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3557535 | 0.85 | ALOX5 (0.45) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1886993-B1 | BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LTD (GB) | 2013-09-18 | — | — | EP | disclosed |
| US-7732622-B2 | Naphthalene derivatives | GLAXO GROUP LIMITED (GB) | 2010-06-08 | — | — | US | disclosed |
| US-20080234358-A1 | E-series of prostaglandin (EP) receptors; [[4-(4,9-dipropoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl) phenyl]acetic acid | CONGREVE MILES STUART | 2008-09-25 | — | — | US | disclosed |
| EP-1886993-A1 | BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2008-02-13 | — | — | EP | disclosed |
| EP-1368312-B1 | BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LTD (GB) | 2007-06-27 | — | — | EP | disclosed |
| US-20070088068-A1 | Benzo[F]Isoindole Derivatives With Affinity To The EP4 Receptor | CONGREVE MILES S | 2007-04-19 | — | — | US | disclosed |
| US-7166631-B2 | Benzo[f]isoindole derivatives with affinity to the EP4 receptor | GLAXO GROUP LIMITED (GB) | 2007-01-23 | — | — | US | disclosed |
| US-20050080257-A1 | Benzo'fisoindole derivatives with affinity to the ep4 receptor | GLAXO GROUP LIMITED (GB) | 2005-04-14 | — | — | US | disclosed |
| EP-1368312-A1 | BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064564-A1 | BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080257-A1 | Benzo'fisoindole derivatives with affinity to the ep4 receptor | PTGER4, PTGER1, PTGER3 | CA12 4739/4885CA1 4638/4885CA2 3248/4885 |
| US-20070088068-A1 | Benzo[F]Isoindole Derivatives With Affinity To The EP4 Receptor | PTGER4, PTGER1, GPR4 | CA12 4627/4885CA1 4372/4885CA2 3626/4885 |
| US-20080234358-A1 | E-series of prostaglandin (EP) receptors; [[4-(4,9-dipropoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl) phenyl]acetic acid | PTGER3, OPRL1, PTGER1 | CA12 1641/4885CA1 1292/4885CA2 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.