Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300333 | 0.86 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| SCHEMBL1567597 | 0.86 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| SCHEMBL229498 | 0.86 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| SCHEMBL566636 | 0.86 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| SCHEMBL2977327 | 0.86 | NISCH (0.71) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| SCHEMBL29437007 | 0.86 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| SCHEMBL30946854 | 0.86 | NISCH (0.71) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| SCHEMBL407262 | 0.85 | HPGD (0.59) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| SCHEMBL13190877 | 0.85 | HPGD (0.59) | HPGDALDH1A1SMN1; SMN2NISCHPOLB | |
| Hydrochloric Acid SCHEMBL7528728 | 0.85 | HPGD (0.59) | HPGDALDH1A1SMN1; SMN2NISCHPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1097192-A | Retroviral protease inhibitors | AMERICAN CYANAMID CO (US) | 1995-01-11 | — | — | CN | claimed |
| US-7834010-B2 | Modulators of peripheral 5-HT receptors | SERODUS AS (NO) | 2010-11-16 | — | — | US | disclosed |
| US-20070254874-A1 | Modulators of Preripheral 5-Ht Receptors | BIO-MEDISINSK INNOVASJON (NO) | 2007-11-01 | — | — | US | disclosed |
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1701951-A2 | MODULATORS OF PERIPHERAL 5-HT RECEPTORS | Bio-Medisinsk Innovasjon AS (NO) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005061483-A2 | MODULATORS OF PERIPHERAL 5-HT RECEPTORS | BIO-MEDISINSK INNOVASJON AS (NO) | 2005-07-07 | — | — | WO | disclosed |
| EP-1112270-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-07-04 | — | — | EP | disclosed |
| US-6172062-B1 | ANTISEROTONIN AGENTS; GASTROINTESTINAL DISORDERS; CARDIOVASCULAR DISORDERS; NERVOUS SYSTEM DISORDERS | SYNTEX (USA) LLC | 2001-01-09 | — | — | US | disclosed |
| WO-2000015636-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-23 | — | — | WO | disclosed |
| CN-1097192-A | Retroviral protease inhibitors | AMERICAN CYANAMID CO (US) | 1995-01-11 | — | — | CN | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254874-A1 | Modulators of Preripheral 5-Ht Receptors | HTR4, HTR5A, HTR6 | HPGD 2909/4885ALDH1A1 3462/4885SMN1; SMN2 2523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.